JPET Highlight: Attenuation of chemotherapy-induced peripheral neuropathy by etodolac
The antiallodynic effect of etodolac increases upon repeated administration therefore, along with safer long term use it may also attenuate the adverse neurological effects of paclitaxel chemotherapy. See article at J Pharmacol Exp Ther 2012, 342 53 60. (JPET 187401)Copyright
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JPET Highlight: Regulation of vemurafenib exposure in the brain by ABC transporters
Intracellular accumulation and brain exposure of vemurafenib was significantly restricted by P gp and BCRP and may significantly impact ongoing trials in brain metastases of melanoma. See article at J Pharmacol Exp Ther 2012, 342 33 40. (JPET 192195)Copyright ©
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JPET Highlight: Lyn kinase activator MLR-1023 potentiates insulin and improves glucose homeostasis
MLR 1023 lowered blood glucose similar to metformin without eliciting a hypoglycemic response, with a faster onset of action than roziglitazone and without causing weight gain. See article at J Pharmacol Exp Ther 2012, 342 23 32. (JPET 192187)Copyright ©
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JPET Highlight: Lyn activation and restoring glucose tolerance
MLR 1023 reduced blood glucose levels without increasing insulin secretion in vivo by allosterically activating the non receptor linked kinase Lyn suggesting a new treatment modality for type 2 diabetes. See article at J Pharmacol Exp Ther 2012, 342 15
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