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Journal Highlights

MI This Month: Getting down to the bone...

In the June 2010 issue of Molecular Interventions, Drake and Cremers discuss the use of biphosphonates to treat bone disease while Schmidt et al review mechanisms and treatment of bone (and other) pain in cancer patients... [6/17/2010] Read more

Posted on 1/1/0001 12:00:00 AM

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JPET Highlight: Amiodarone is a Selective Allosteric Modulator of the M5-Muscarinic Receptor

Muscarinic orthosteric site modulators that have high affinity for muscarinic receptors are usually not highly selective, limiting their usefulness as therapeutics. Stahl and Ellis are the first to demonstrate an allosteric enhancement of efficacy but not potency at any muscarinic receptor and that amiodarone is a novel M5-selective positive allosteric modulator of muscarinic receptors.[6/16/2010] Read more

Posted on 1/1/0001 12:00:00 AM

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