JPET Highlight: Regulation of vemurafenib exposure in the brain by ABC transporters
Posted on 1/1/0001 12:00:00 AM
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Intracellular accumulation and brain exposure of vemurafenib was significantly restricted by P-gp and BCRP and may significantly impact ongoing trials in brain metastases of melanoma. See article atJ Pharmacol Exp Ther 2012, 342:33-40. (JPET 192195)
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