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JPET Highlight: Regulation of vemurafenib exposure in the brain by ABC transporters

Posted on 1/1/0001 12:00:00 AM | Tags:

Intracellular accumulation and brain exposure of vemurafenib was significantly restricted by P-gp and BCRP and may significantly impact ongoing trials in brain metastases of melanoma. See article atJ Pharmacol Exp Ther 2012, 342:33-40. (JPET 192195)

Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

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