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JPET Highlight: Treating Parkinson’s disease with selective dopamine D4 antagonists

Posted on 1/1/0001 12:00:00 AM | Tags:

 

Oral administration of the dopamine D4 antagonist, L-745,870 in combination with L-DOPA significantly alleviates dyskinesia. Importantly, the anti-dyskinetic efficacy was achieved without compromising L-DOPA anti-parkinsonian benefit, thereby identifying D4 receptors as a promising target for dyskinesia. See article at J Pharmacol Exp Ther 2012, 342:576–585. (JPET 195693)

Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

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