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JPET Highlight: Vascular Disrupting Agent, STA-9584, Targets Microvascular at the Center and Periphery of Tumor

Posted on 10/17/2012 11:44:12 AM

Vascular disrupting agents are an emerging class of therapeutics targeting the vascular network of solid tumors. However, clinical progression has been hampered, primarily due to the persistence of surviving cells in the well perfused areas of tumors. STA-9584 demonstrates activity in well perfused areas of the tumor identifying it as a promising new therapeutic candidate. See article at J Pharmacol Exp Ther 2012, 343:529–538. (JPET 196873)

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