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JPET Highlight: Strontium is a Biased Agonist of the Calcium-Sensing Receptor

Posted on 11/15/2012 5:28:18 PM

The calcium-sensing receptor specific allosteric modulator, cinacalcet, is used to treat secondary hyperparathyroidism in patients with chronic kidney disease. Due to hypocalcemic side effects, clinical application is limited. The results of the present study suggest that calcitonin secretion can be affected by CaSR-stimulated signaling bias. See article at J Pharmacol Exp Ther 2012, 343:638–649. (JPET 197210)

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