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General Principles of Pharmacology and Therapeutics - Methodology/Model Systems/Mechanisms

Macromolecular Therapeutics: Emerging Strategies for Drug Discovery in the Postgenome Era
R.L. Juliano, A. Astriab-Fisher, and D. Falke
Mol Interv April 2001 1:40-53


Characterizing Proteins of Unknown Function: Orphan Cytochrome P450 Enzymes as a Paradigm
F. Peter Guengerich, Zhongmei Tang, S. Giovanna Salamanca-Pinzón, and Qian Cheng
Mol Interv June 2010 10:153-163; doi:10.1124/mi.10.3.6


Systemic Administration of Naked DNA: Gene Transfer to Skeletal Muscle

Feng Liu, Kenneth W. Liang, and Leaf Huang
Mol Interv August 2001 1:168-172


Expression Array Technology in the Diagnosis and Treatment of Breast Cancer
Stefanie S. Jeffrey, Michael J. Fero, Anne-Lise Børresen-Dale, and David Botstein
Mol Interv April 2002 2:101-109; doi:10.1124/mi.2.2.101


Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Therapy

Thomas Tuschl and Arndt Borkhardt
Mol Interv June 2002 2:158-167; doi:10.1124/mi.2.3.158


Caenorhabditis elegans in Parkinson’s Disease Drug Discovery: Addressing an Unmet Medical Need

Richard Nass, Kalpana M. Merchant, and Timothy Ryan
Mol Interv December 2008 8:284-293; doi:10.1124/mi.8.6.6


Pharmacokinetic Assessment of Multiple ATP-binding Cassette Transporters: The Power of Combination Knockout Mice

Jurjen S. Lagas, Maria L.H. Vlaming, and Alfred H. Schinkel
Mol Interv June 2009 9:136-145; doi:10.1124/mi.9.3.7


Drosophila: A “Model” Model System To Study Neurodegeneration
Alicia M. Celotto and Michael J. Palladino
Mol Interv October 2005 5:292-303; doi:10.1124/mi.5.5.9


Regenerative Pharmacology: The Future is Now
Karl-Erik Andersson and George J. Christ
Mol Interv April 2007 7:79-86; doi:10.1124/mi.7.2.8


Translational NeuroImaging of the CNS: Novel Pathways to Drug Development

Gerard B. Fox, Chih-Liang Chin, Feng Luo, Mark Day, and Bryan F. Cox
Mol Interv December 2009 9:302-313; doi:10.1124/mi.9.6.6


Serotonin 5-HT2 Receptors: Molecular and Genomic Diversity
Elaine Sanders-Bush, Hugh Fentress, and Lisa HazelwoodMolecular
Mol Interv September 2003 3:319-330; doi:10.1124/mi.3.6.319


Biochemical Mechanisms of Cyclosporine Neurotoxicity

Natalie J. Serkova, Uwe Christians, and Leslie Z. Benet
Mol Interv April 2004 4:97-107; doi:10.1124/mi.4.2.7


Antibody Conjugates and Therapeutic Strategies
Paul A. McCarron, Shane A. Olwill, Waleed M.Y. Marouf, Richard J. Buick, Brian Walker, and Christopher J. Scott
Mol Interv December 2005 5:368-380; doi:10.1124/mi.5.6.9


Regulation of Receptors and Transporters by Ubiquitination: New Insights into Surprisingly Similar Mechanisms
Manuel Miranda and Alexander Sorkin
Mol Interv June 2007 7:157-167; doi:10.1124/mi.7.3.7


Recombinant Pharmaceuticals from Plants: The Plant Endomembrane System as Bioreactor
Alessandro Vitale and Emanuela Pedrazzini
Mol Interv August 2005 5:216-225; doi:10.1124/mi.5.4.5


Networking with AKAPs: Context-dependent Regulation of Anchored Enzymes

Emily J. Welch, Brian W. Jones, and John D. Scott
Mol Interv April 2010 10:86-97; doi:10.1124/mi.10.2.6


The Biology of Caveolae: Lessons from Caveolin Knockout Mice and Implications for Human Disease

Robert Hnasko and Michael P. Lisanti
Mol Interv December 2003 3:445-464; doi:10.1124/mi.3.8.445

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What is Pharmacology?

Pharmacology is the science of drug action on biological systems. In its entirety, pharmacology embraces knowledge of the sources, chemical properties, biological effects and therapeutic uses of drugs. Learn more!