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Pharmacology of Organ Systems and Disease - Organ Systems

Bone

Bisphosphonate Therapeutics in Bone Disease: The Hard and Soft Data on Osteoclast Inhibition
Matthew T. Drake and Serge C.L.M. Cremers
Mol Interv June 2010 10:141-152; doi:10.1124/mi.10.3.5


Strontium Ranelate in Osteoporosis and Beyond: Identifying Molecular Targets in Bone Cell Biology
Pierre J. Marie
Mol Interv October 2010 10:305-312; doi:10.1124/mi.10.5.7

Cardiovascular


Non-nuclear Actions of Estrogen: New Targets for Prevention and Treatment of Cardiovascular Disease
Karen J. Ho and James K. Liao
Mol Interv July 2002 2:219-228; doi:10.1124/mi.2.4.219

The “Heartbreak” of Older Age
Edward G. Lakatta and Steven J. Sollott
Mol Interv November 2002 2:431-446; doi:10.1124/mi.2.7.431


Phosphorylation of G Protein–Coupled Receptors: GPCR Kinases in Heart Disease
Jonathan A. Hata and Walter J. Koch
Mol Interv August 2003 3:264-272; doi:10.1124/mi.3.5.264


Low-Dose Aspirin, Coxibs, and other NSAIDS: A Clinical Mosaic Emerges
Carlo Patrono and Colin Baigent
Mol Interv February 2009 9:31-39; doi:10.1124/mi.9.1.8


Antioxidants in Hypertension and Cardiovascular Disease
Ernesto L. Schiffrin
Mol Interv December 2010 10:354-362; doi:10.1124/mi.10.6.4


Mechanism of Tissue-Selective Drug Action in the Cardiovascular System
Terrance D. Barrett, David J. Triggle, Michael J.A. Walker, and Donald H. Maurice
Mol Interv April 2005 5:84-93; doi:10.1124/mi.5.2.6


Antifibrillatory Agents and Potassium Channels in the Atria: Pore Block versus Channel Trafficking
Dyke P. McEwen and Jeffrey R. Martens
Mol Interv April 2009 9:79-86; doi:10.1124/mi.9.2.7


The Cardiotoxicology of Anthracycline Chemotherapeutics: Translating Molecular Mechanism Into Preventative Medicine
Xuyang Peng, Billy Chen, Chee Chew Lim, and Douglas B. Sawyer
Mol Interv June 2005 5:163-171; doi:10.1124/mi.5.3.6


Na+-K+–ATPase-Mediated Signal Transduction: From Protein Interaction to Cellular Function
Zijian Xie and Ting Cai
Mol Interv May 2003 3:157-168; doi:10.1124/mi.3.3.157

Smooth Muscle

Vasomotion: Mechanisms and Physiological Importance
Holger Nilsson and Christian Aalkjær
Mol Interv March 2003 3:79-89; doi:10.1124/mi.3.2.79


RHO Signaling in Vascular Diseases
Tammy M. Seasholtz and Joan Heller Brown
Mol Interv December 2004 4:348-357; doi:10.1124/mi.4.6.8


Secretory Functions of Smooth Muscle: Cytokines and Growth Factors
William T. Gerthoffer and Cherie A. Singer
Mol Interv November 2002 2:447-456; doi:10.1124/mi.2.7.447

Vascular/Endothelium

Fibrin Mechanisms and Functions in Nervous System Pathology
Ryan A. Adams, Melissa Passino, Benjamin D. Sachs, Tal Nuriel, and Katerina Akassoglou
Mol Interv June 2004 4:163-176; doi:10.1124/mi.4.3.6


Estrogen and Mitochondria: A New Paradigm for Vascular Protection?
Sue Piper Duckles, Diana N. Krause, Christopher Stirone, and Vincent Procaccio
Mol Interv February 2006 6:26-35; doi:10.1124/mi.6.1.6


Advanced Drug Delivery Systems That Target The Vascular Endothelium
Bi-Sen Ding, Thomas Dziubla, Vladimir V. SSilvia Muro, and Vladimir R. Muzykantov
Mol Interv April 2006 6:98-112; doi:10.1124/mi.6.2.7


Molecular Mechanisms of SERT in Platelets: Regulation of Plasma Serotonin Levels
Charles P. Mercado and Fusun Kilic
Mol Interv August 2010 10:231-241; doi:10.1124/mi.10.4.6


NOX Isoforms and Reactive Oxygen Species in Vascular Health
Rhian M. Touyz, Ana M. Briones, Mona Sedeek, Dylan Burger, and Augosto C. Montezano
Mol Interv February 2011 11:27-35; doi:10.1124/mi.11.1.5


Proteases Display Biased Agonism at Protease-Activated Receptors: Location matters!
Angela Russo, Unice J. K. Soh, and JoAnn Trejo
Mol Interv April 2009 9:87-96; doi:10.1124/mi.9.2.8

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What is Pharmacology?

Pharmacology is the science of drug action on biological systems. In its entirety, pharmacology embraces knowledge of the sources, chemical properties, biological effects and therapeutic uses of drugs. Learn more!