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G protein-β-arrestin Interplay: Molecular and Therapeutic Implications

Sunday April 07, 2019

8:00 am - 10:00 am Eastern Time (ET)

Room W205 BC

DDD MP TCP

Chair :

Douglas Tilley
Temple Univ School of Medicine

Yang Xiang
University of California at Davis



GPCRs proximally engage G proteins and β-arrestins to relay various effects at the receptor, cellular and physiologic levels. Recent drug discovery efforts have focused on the preferential engagement of either G proteins or β-arrestins to exert specific signaling outcomes. However, several studies have begun to highlight the complex interplay between G proteins and β-arrestins that complicate our understanding of these signaling paradigms. Thus, this session will highlight the latest concepts with regard to the ligand bias and the molecular relationship between G proteins and β-arrestins, as well as their application to relevant cell types and desired therapeutic outcomes.

Speakers

Arun Shukla - Indian Institute of Technology Kanpur

Structural Insights Into G protein and β-arrestin Interplay at the Receptor

Evi Kostenis - University of Bonn

Upstream-Downstream-Parallel: A Fresh Perspective on Hierarchies of GPCR Transducers

J. Silvio Gutkind - Univ of California, San Diego

β-arrestin-independent G Protein Signaling

Laura Bohn - The Scripps Research Institute

Ligand Bias and Therapeutic Efficacy

Michael Ippolito - Thomas Jefferson University

Negative Allosteric Modulation of Arrestin Recruitment to the β2-Adrenergic Receptor

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019