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 Lori
Ann Birder
University of Pittsburgh School of Medicine
Department of Medicine
Renal-Electrolyte Division
A1207 Scaife Hall
Pittsburgh, PA 15261
Business Phone: (412) 383-7368
Business Fax: (412) 648-7197
Email Address: lbirder+@pitt.edu
PUBLICATIONS
REFEREED ARTICLES:
1. Birder LA, Roppolo JR, Iadarola MJ and de Groat WC. Electrical
stimulation of visceral afferent pathways in the pelvic nerve increases
c-fos in the rat lumbosacral spinal cord. Neuroscience Letters,
29:193-196, 1991.
2. Foglia JP, Birder LA and Perel JP. A new method for the determination
of fluvoxamine in human plasma for HPLC with ultraviolet detection.
Journal of Chromatography, 495:295-302, 1989.
3. Birder LA and de Groat WC. The effect of glutamate antagonists on c-fos
expression induced in spinal neurons after irritation of the lower
urinary tract. Brain Research, 580:115-120,1992.
4. de Groat WC, Birder LA, Morgan CW, Roppolo JR, Yoshiyama M and Suzuki
T. Recent developments in the neuropharmacology and neurophysiology of
the lower urinary tract. Neurourology and Urodynamics, 1992.
5. Birder LA and de Groat WC. Increased c-fos expression in spinal
neurons after chemical irritation on the lower urinary tract in the rat.
Journal of Neuroscience, 12:4878-4889, 1992.
6. Birder LA and de Groat WC. Induction of c-fos gene expression of
spinal neurons of the rat by nociceptive and non-nociceptive stimulation
of the lower urinary tract. American Journal of Physiology,
265:R326-R333, 1993.
7. Kawatani M, Matsumoto G, Birder LA, Fukuoka H, Yoshiyama M and Misaki
A. Intrathecal administration of NK1 receptor antagonist CP96345,
inhibits the micturition reflex in the rat. Regulatory Peptides,
46:392-395, 1993.
8. Kanai AJ, Mesaros S, Finkel MS, Oddis CV, Birder LA and Malinski T.
Adrenergic regulation of constitutive nitric oxide synthase in cardiac
myocytes. American Journal of Physiology, 273:C1371-1377, 1997.
9. Birder LA, Kanai AJ and de Groat WC. DMSO: Effect on bladder afferent
neurons and nitric oxide release. Journal of Urology, 158:1989-1995,
1997.
10. Birder LA, Apodaca G, de Groat WC and Kanai AJ. Adrenergic and
capsaicin evoked nitric oxide release from urothelium and afferent
nerves in urinary bladder. American Journal of Physiology, 275:F226-229,
1998.
11. Birder LA and de Groat WC. Contribution of C-fiber afferent nerves
and autonomic pathways in the urinary bladder to spinal c-fos expression
induced by bladder irritation. Somatosensory and Motor
Research,15(1):5-12, 1998.
12. Birder LA, Roppolo JR, Erickson VE and de Groat WC. Increased c-fos
expression in spinal projection and preganglionic neurons after
irritation of the lower urinary tract in the rat. Brain Research,
834:55-69, 1999.
13. Birder LA and Perl ER. Expression of 2A adrenergic receptors in rat
primary afferent neurones after peripheral nerve injury or inflammation.
Journal of Physiology (London), 515.2:533-542, 1999.
14. Lecci A., Birder LA, Meini S., Catalioto R.M., Tramontana M.,
Giuliani S., Criscuoli M. and Maggi CA. The role of cyclooxygenase
isoenzymes on the micturition reflex following experimental
inflammation. British Journal of Pharmacology, 130:331-338, 2000.
15. Lecci A., Carini F., Tramontana M., Birder L., de Groat W.,
Santicioli P., Giuliani S., Maggi CA. Effects of capsaicin in the rat
and hamster urinary bladder. Autonomic Neuroscience, 91:37-46, 2001.
16. S. Kiss, M. Yoshiyama, Y.Q. Cao, A.I. Basbaum, W.C. de Groat, A.
Lecci, C.A. Maggi and L.A. Birder. Impaired response to chemical
irritation of the urinary tract in mice with disruption of the
preprotachykinin gene. Neuroscience Letters. 313:57-60, 2001.
17. Kanai AJ, Pearce LL, Clemens PR, Birder LA, VanBibber MM, Choi SY,
de Groat WC and Peterson J. Identification of a neuronal nitric oxide
synthase in isolated cardiac mitochondria using electrochemical
detection. Proceedings of the National Academy of Sciences (USA),
98(24):14126-14131, 2001.
18. S. Tirney, CE Mattes, N Yoshimura, T Yokayama, H Ozawa, E Tzeng, LA
Birder, AJ Kanai, J Huard, WC de Groat and M Chancellor. Nitric oxide
synthase therapy for erectile dysfunction: comparison of plasmid,
adenovirus, and adenovirus-transduced myoblast vectors. Molecular
Urology, 5:37-43, 2001.
19. LL Pearce, AJ Kanai, LA Birder, BR Pitt and J Peterson. The
catabolic fate of nitric oxide: the nitric oxide oxidase and
peroxynitrite reductase activities of cytochrome oxidase. Journal of
Biological Chemistry, 277(16):13556-13562, 2002.
20. Birder LA, Kanai AJ, de Groat WC, Kiss S, Nealen M.L., Burke N.E.,
Dineley K.E., Watkins S, Reynolds I.J., and Caterina M.J. Functional
vanilloid receptors in non-neuronal urinary bladder epithelial cells.
Proceedings of the National Academy of Sciences (USA),
98(23):13396-13401, 2001.
21. Kreiss C, Birder LA, Kiss S and Bauer AJ. COX-2 dependent
inflammation activates intestinal primary afferents during rodent
postoperative ileus. GUT, 52:527-534, 2002.
22. Anthony J Kanai, Mark L Zeidel, John P Lavelle, Joel Greenberger,
Lori A Birder, William C de Groat, Gerard L Apodaca, Susan A Meyers,
Richard Ramage and Michael Epperly. Manganese superoxide dismutase gene
therapy protects against irradiation-induced cystitis. American Journal
of Physiology, 283:F1304-12, 2002.
23. Birder LA, Nealen M, Kiss S, de Groat WC, Caterina MJ, Wang E,
Apodaca G and Kanai AJ. -adrenergic agonists stimulate endothelial
nitric oxide synthase in rat urinary bladder urothelial cells. Journal
of Neuroscience, 22(18):8063-8070, 2002.
24. Birder LA, Nakamura Y, Kiss S, Nealen M, Barrick S, Kanai AJ, Wang
E, Ruiz G, de Groat WC, Apodaca G, Watkins S and Caterina MJ. Altered
bladder function in mice lacking the vanilloid receptor TRPV1. Nature
Neuroscience, 5(9):856-890, 2002.
25. Lori A. Birder, Susanna Kiss, William C. de Groat, Alessandro Lecci
and Carlo A. Maggi. Effect of nepadutant, an NK2 tachykinin receptor
antagonist, on immediate-early gene expression following
trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat. Journal
of Pharmacology and Experimental Therapeutics, 304:272-6, 2003.
26. Apodaca G, Kiss S, Ruiz WG, Meyers S, Zeidel M and Birder L.
Disruption of bladder epithelium barrier function after spinal cord
injury. American Journal of Physiology, 284: F966-976, 2003.
27. Chancellor MB, Tirney S, Mattes CE, Tzeng E, Birder LA, Kanai AJ, de
Groat WC, Huard J, Yoshimura N. Nitric oxide synthase gene transfer for
erectile dysfunction in a rat model. BJU International, 91: 691-696,
2003.
28. Birder LA, Barrick S, Roppolo JR, Kanai AJ, de Groat WC, Kiss S and
Buffington CA. Feline interstitial cystitis results in mechanical
hypersensitivity and altered ATP release from bladder urothelium.
American Journal of Physiology, 285:F423-429, 2003.
29. Kanai A, Epperly M, Pearce L, Birder L, Zeidel M, Meyers S,
Greenberger J, de Groat W, Apodaca G and Peterson J. Differing roles of
mitochondrial nitric oxide synthase in cardiomyocytes and urothelial
cells. American Journal of Physiology, 286:H13-H21, 2004.
30. Archaya P, Beckel J, Ruiz WG, Wang E, Rojas R, Birder L and Apodaca
G. Distribution of the tight junction proteins ZO-1, Occludin, and
Claudin-4, -8 and –12 in bladder epithelium. American Journal of
Physiology, 287:F305-F318, 2004.
31. Birder LA, Ruan HZ, Chopra B, Xiang Z, Barrick S, Buffington CA,
Roppolo JR, Ford AP, de Groat WC and Burnstock G. Alterations in P2X and
P2Y purinergic receptor expression in urinary bladder from normal cats
and cats with interstitial cystitis. American Journal of Physiology,
287:F1084-1091, 2004.
32. Bikramjit Chopra, Stacey R. Barrick, Susan Meyers, Jonathan M.
Beckel, Mark L. Zeidel, Anthony P.D.W. Ford, William C. de Groat and
Lori A. Birder. Expression and function of bradykinin B1 and B2
receptors in normal and inflamed rat urinary bladder urothelium. Journal
Physiology (London), 562:859-871, 2005.
33. JR Roppolo, C Tai, AM Booth, CA Buffington, WC de Groat and LA
Birder. Bladder A afferent nerve activity in normal cats and cats with
feline interstitial cystitis. Journal of Urology, 173:1011-1015, 2005.
34. Birder LA, Wolf-Johnston A, Buffington CA, Roppolo JR, de Groat WC
and Kanai AJ. Altered inducible nitric oxide synthase expression and
nitric oxide production in urinary bladder from cats with feline
intersitial cystitis. Journal of Urology, 173:625-629, 2005.
35. Sculptoreanu A, Buffington CA, de Groat WC and Birder LA. Abnormal
excitability in capsaicin-responsive DRG neurons from cats with feline
interstitial cystitis. Experimental Neurology, 193:437-443, 2005.
36. Sculptoreanu A, Buffington CA, de Groat WC and Birder LA. Protein
kinase C contributes to abnormal capsaicin responses in DRG neurons from
cats with feline interstitial cystitis. Neuroscience Letters, 381:42-46,
2005.
37. Ruan Huai-Zhen, Birder Lori, de Groat William, Tai Changfeng,
Roppolo James, Buffington Charles and Burnstock Geoffrey. Localization
of P2X and P2Y receptors in dorsal root ganglia of the cat. Journal of
Histochemistry and Cytochemistry, 53:1273-1282, 2005.
38. Edward C.Y. Wang, Jey-Meung Lee, Wily G. Ruiz, Elena M. Balestreire,
Maximillian von Bondungen, Stacey Barrick, Debra Cockayne, Lori A.
Birder and Gerald Apodaca. ATP and purinergic receptor-membrane traffic
in bladder umbrella cells. Journal of Clinical Investigation,
115:2412-22, 2005.
39. Beckel JM, Kanai A, Lee SJ, de Groat WC and Birder LA. Expression of
functional nicotinic acetylcholine receptors in rat urinary bladder
epithelial cells. American Journal of Physiology, 290:F103-F110, 2006.
40. Ruan HZ, Birder LA, Xiang Z, Chopra B, Buffington T, Tai C, Roppolo
JR, de Groat WC and Burnstock G. Expression of P2X and P2Y receptors in
the intramural parasympathetic ganglia of the cat urinary bladder.
American Journal of Physiology, 2006: 290:F1143-1152.
41. Chaoming Zhou, Chandra Ziegler, Lori A. Birder, Alexandre F.R.
Stewart and Edwin S. Levitan. Angiotensin II and stretch activate NADPH
oxidase to destabilize cardiac Kv4.3 channel mRNA. Circulation Research,
2006: 98:1040-1047.
42. Birder LA, Griffiths D, Wolf-Johnston A and Resnick N. Role of
Urothelial Nerve Growth Factor in Human Bladder Function. Neurourology
and Urodynamics, 26:405-409, 2007
43. Kanai AJ, Roppolo J, Ikeda Y, Zabbarova I, Tai C, Birder LA,
Griffiths D, de Groat WC and Fry CH. Origin of spontaneous activity in
neonatal and adult rat bladders and its enhancement by stretch and
muscarinic agonists. American Journal of Physiology, 292:F1065-1072,
2007.
44. A.T. Hanna-Mitchell, J.M. Beckel, S. Barbadora, A.J. Kanai, W.C. de
Groat and L.A. Birder. Non-neuronal acetylcholine and urinary bladder
urothelium. Life Sciences, 80:2298-302, 2007.
45. Lori Birder, F. Aura Kullman, Hyosang Lee, Stacey Barrick, William
de Groat, Anthony Kanai and Michael Caterina. Activation of
urothelial-TRPV4 by 4-PDD contributes to altered bladder reflexes in
the rat. Journal of Pharmacology and Experimental Therapeutics,
323:227-35, 2007.
46. F. Aura Kullman, D. Artim, L. Birder and W.C. de Groat. Activation
of muscarinic receptors in rat bladder sensory pathways alters reflex
bladder activity. Journal of Neuroscience, in press, 2008.
47. B.Chopra, J.Gever, S.R. Barrick, A.T. Hanna-Mitchell, J.M. Beckel,
A.P.D.W. Ford and L.A. Birder. Expression and function of rat urothelial
P2Y receptors. American Journal of Physiology, in press, 2008.
48. Beatrice M. Girard, Amanda Wolf-Johnston, Karen M. Braas, Lori A.
Birder and Margaret A. Vizzard. PACAP/VIP and receptor characterization,
regulation and function in micturition pathways. Journal of Molecular
Neuroscience, in press, 2008.
49. Kullman F, Artim D, Beckel J, Barrick, de Groat WC and Birder L.
Heterogeneity of muscarinic receptor mediated Ca2+ responses in cultured
urothelial cells from rat. American Journal of Physiology, in press,
2008.
NON REFEREED ARTICLES:
New Scientist, March 20, 1999; “Why the Pain of Wounds Comes Back to
Haunt You”.
Interstitial Cystitis Network, 1999; “The Role of Nitric Oxide in
Interstitial Cystitis”.
Pitt Med Magazine, 2004, “Cells lining the Bladder are Similar to
Nerves”.
BOOK CHAPTERS / INVITED REVIEWS:
1. Kawatani M, Birder LA, Weight FF, White G, Matsumoto G, Roppolo JR
and de Groat WC. Nociceptive afferent pathways innervating the
urogenital tract. In: Symposium Proceedings, Elsevier Series, Excepta
Medica Internal Congress, (R. Inoki, Y. Shigenaga and M. Tohyama, eds),
pp.15-21, 1992.
2. Birder LA and Perl ER. Cutaneous Sensory Receptors. In: H. Luders,
ed. J. Clinical Neurophysiology. New York: Raven Press, Ltd.,
1994:534-552.
3. Lecci A, L. Birder, Meini S, Giuliani S, Tramontana M, Crisuoli M and
Maggi CA. Capsaicin and the micturition reflex: Actions of tachykinins
and other transmitters. Research Trends: Current Topics in Pharmacology,
4:199-220, 1999.
4. Birder LA. Involvement of the urinary bladder urothelium in signaling
in the lower urinary tract.
Proc West Pharmacol Soc., 44:85-6, 2001.
5. Birder LA. Role of the urothelium in bladder function. Scand. Journal
of Urology and Nephrology, 215:48-53, 2004.
6. Birder LA. More than just a Barrier: Urothelium as a Drug Discovery
Target for Urinary Bladder Pain. Invited Review, American Journal of
Physiology, 289:F489-95, 2005.
7. Birder LA. Urinary Bladder Urothelium: Molecular Sensors of
Chemical/Thermal/Mechanical Stimuli. Invited Review, Vascular
Pharmacology, 45:221-6, 2006.
8. J. Morrison, L. Birder, M. Craggs, W. de Groat, J. Donie, M. Drake,
C. Fowler and K. Thor. Neural Control. In: Paul Abrams, Linda Cardozo,
Saad Khoury and Alan Wein eds. Incontinence: Basics and Evaluation.
Volume 1, Chapter 3, pps 363-422, 2005.
9. Birder LA. Review: Physiology of bladder urothelium. AUA Update
Series, lesson 25, 2006.
10. Birder LA. Urothelium as a Pain Organ. In: The Senses: A
Comprehensive Reference. (Ronald R. Hoy, Gordon M. Shepherd, Allan I.
Basbaum, Akimichi Kaneko and Gerald Westheimer, eds). Oxford, Elsevier,
in press, Chapter 3, 2007.
11. Yoshimura N and Birder LA. Interstitial cystitis and related painful
bladder syndromes: pathophysiology. In: J. Pasricha, W. Willis and G.
Gebhart, eds. Chronic Abdominal and Visceral Pain: Theory and Practice.
2006.
12. Birder LA. Role of the Urothelium in Urinary Bladder Dysfunction
following Spinal Cord Injury. In: L.C. Weaver, ed. Progress in Brain
Research, 152: 135-146, 2006.
13. Kanai A, de Groat W, Birder L, Chai T, Hultgren S, Fowler C and Fry
C. Urothelium dysfunction: pathophysiology and novel therapeutics.
Journal of Urology, 175:1624-1629, 2006.
14. Birder L, Kanai A, Liebert M and Saban R. Research priorities in
urothelial cell physiology. The Physiologist, 49:106-111, 2006.
15. Yoshimura N and Birder LA. Urothelial and afferent mechanisms
inducing pain in interstitial cystitis. Journal of Neuropathic Pain &
Symptom Palliation, 2:3-22, 2006.
16. Lori A. Birder and William C. de Groat. The Urothelium as a Sensory
Organ. Nature Clinical Practice Urology, 4:46-54, 2007.
17. Anand K. Patel, Christopher R. Chapple, Heinz Koelbl, Karl-Erik
Andersson and Lori Birder. What’s Hot from the ICS Annual Meeting 2006.
Neurourology and Urodynamics, 1-6, 2007.
18. Gerard Apodaca, Elena Balestreire and Lori A. Birder. The
uroepithelial-associated sensory web. Kidney International, 72:1057-64,
2007.
19. LA Birder. TRPs in Bladder Disease. BBA Molecular Mechanisms of
Disease. 1772:879-84, 2007.
RESEARCH:
Sources of Active Research Support
Nitric Oxide in Bladder Neural-Epithelial Signaling (MERIT AWARD)
Principal Investigator: Lori A. Birder, Ph.D.
Agency: NIH/NIDDK; Type: R37 DK54824-08; Period: 4/01/07-3/31/17
Goals: This competing renewal focuses on intracellular signaling
mechanisms underlying the neuron-like properties of urothelial cells,
urothelial-cell interactions and evaluate the effect of pathology on
urothelial properties/signaling.
Role of Nitric Oxide in Interstitial Cystitis
Principal Investigator: Lori A. Birder, Ph.D.
Agency: NIH/NIDDK; Type: R01 DK57284-06; Period: 8/01/05-7/31/09
Goals: The goals of this project are to identify how alterations in NO
production (and other mediators) may play a role in the pathophysiology
of interstitial cystitis (IC) studied in cats with a naturally occurring
form of IC (feline interstitial cystitis)
Effects of Estrogens and Inflammation on Bladder Pain
Principal Investigator: Janet Keast, Ph.D.
Role in Project: Co-PI
Agency: NIH/NIDDK; Type: R01 DK069351; Period: 09/01/05-08/31/10
Goals: The goals of this grant are to understand the mechanism by which
estrogens affect the detection of noxious stimuli by the urinary
bladder.
Mechanisms of Autonomic Neuropathy in Bladder Complications of Diabetes
Principal Investigator: Firouz Danesghari, M.D.
Role in Project: Co-PI
Agency: National Juvenile Diabetes Foundation; Period: 10/01/06-09/30/08
Goals: The goals of this grant are to understand how accumulation of
reactive oxygen species may play a role in autonomic and urothelial
dysfunction in STZ induced diabetes in rats.
Women’s Health and Functional Visceral Disorders Center
Principal Investigator: Emeran Mayer, M.D.
Role in Project: PI-project IV
Agency: NIH/NIDDK; Type: Specialized Centers of Research (SCOR) RFA;
Period: 7/01/07-6/30/12
Goals: To assess the effect of estrogen and CRF on urothelial function
under basal and stress related conditions in IC cats.
Study of Intrinsic Bladder Activity by Optical Imaging
Principal Investigator: Anthony Kanai, Ph.D.
Role in Project: Co-PI
Agency: NIH/NIDDK; Type: R01 DK064280; Period: 01/14/04-11/30/07
Goals: To investigate the postnatal modulation of intrinsic bladder
activity, the neural-chemical control of spontaneous activity and the
origin of unstable bladder activity in partially obstructed bladders.
Neurotrophic Mechanisms in LUT Plasticity with Cystitis
Principal Investigator: Margaret Vizzard, Ph.D.
Role in Project: Co-PI
Agency: NIH/NIDDK; Type: R01 DK065989; Period: 09/30/03-07/31/07
Goals: To investigate the role of PACAP in bladder urothelial-neural
function and whether properties are altered following inflammation.
Endocytic and Exocytic Traffic in Bladder Uroepithelium
Principal Investigator: Gerald Apodaca, Ph.D.
Role in Project: Consultant
Agency: NIH/NIDDK; Type: R01 DK054425; Period: 05/01/04-04/30/09
Goals: To evaluate the effect of diuresis on exocytosis, endocytosis and
signaling cascades in bladder urothelium.
Roles of nitric oxide and superoxide in cystitis
Principal Investigator: Anthony J. Kanai, Ph.D.
Role in Project: Co-PI
Agency: NIH/NIDDK; Type: RO1 DK07085; Period: 04/01/05-03/31/10
Goals: The goals of this grant are to investigate the involvement of NO
and superoxide following induction of radiation cystitis.
Role of TRPV Channels in pain and Temperature Sensation
Principal Investigator: Michael J. Caterina, M.D., Ph.D.
Role in Project: Co-PI
Agency: NIH/NINDS; Type: R01 NS051551; Period: 07/01/05-06/30/10
Goals: The goals of this grant will be to evaluate the role of TRP
channels in thermosensation and nociception and the mechanisms by which
keratinocytes communicate the presence of thermal stimuli to sensory
neurons.
Pending:
Evaluation of Stimulus-evoked membrane trafficking in bladder urothelial
cells
Principal Investigator: Ann Hanna-Mitchell, Ph.D.
Role in Project: Sponsor
Agency: NIH/NIDDK; Type: K01; Period: 10/01/07-9/30/12
Goals: To utilize fluorescent dyes to track the movement of stimulus
evoked dye-filled vesicles in order to provide information as to the
trafficking events underlying transmitter release by urothelial cells.
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