Edward Morgan

 

Edward T. Morgan , Ph.D. Professor Department of Pharmacology Emory University Atlanta, GA 30322 e-mail: etmorga@emory.edu

Edward T. (Eddie) Morgan was born in Millport, Isle of Cumbrae, Scotland. He received a B.Sc. (Honours) in Pharmacology from the University of Glasgow in 1976, and a Ph.D. in Pharmacology from the University of Glasgow in 1979. (Advisors Garth Powis and Paul Skett). As a Postdoc with Minor J Coon at the University of Michigan from 1979-82, Dr. Morgan teamed with Dr. Dennis Koop to identify, purify and characterize a novel ethanol-induced P450 protein, CYP2E1. This enzyme plays an important role in the toxicology of many compounds, and may also contribute to alcohol-induced oxidative stress. He then moved to the Karolinska Institute in Stockholm, Sweden where, working as a Visiting Scientist with Prof. Jan-Åke Gustafsson from 1982-86, he was the first to conclusively demonstrate that expression of sex-specific forms of cytochrome P450 in rodents are regulated by the pulsatile pattern of Growth Hormone secretion.

In 1986, he joined the faculty at Emory University, where he is now Professor of Pharmacology; Director of the Graduate Program in Molecular and Systems Pharmacology; and a member of the Drug Discovery and Development Division of the Winship Cancer Institute. Dr. Morgan’s research interests at Emory have been focused on the regulation of hepatic cytochrome P450 enzymes by inflammatory and infectious stimuli, and provided the first evidence that such regulation occurs via suppression of gene transcription. His current research interests are in interactions between host P450s and invading bacteria in a model of gastrointestinal infection and inflammatory bowel disease; and on post-translational regulation of P450s with a focus on Nitric Oxide. Dr. Morgan has been the recipient of various awards including: Visiting Scientist Fellowships from the Swedish Medical Research Council and the Swedish Work Health Fund; a Faculty Development Award from the Pharmaceutical Manufacturer’s Association Foundation; and the Joseph G. Williams Memorial Lectureship from the University of South Florida. Dr. Morgan is a member of the American Society of Pharmacology and Experimental Therapeutics, the American Society of Biochemistry and Molecular Study Biology, the Society of Toxicology and the International Society for the Study of Xenobiotics. He served as Chair of the Drug Metabolism and Disposition Division of ASPET, and is a member of the ASPET Board of Publications Trustees. He is a former Associate Editor of Molecular Pharmacology, and currently serves on the Editorial Board of Drug Metabolism and Disposition. Dr. Morgan also served as a regular member on the Pharmacology and XNDA Study Sections of the NIH, and on the Pharmacology Test Committee of the National Board of Medical Examiners.

Recent Publications:

Ferrari L, Peng N, Halpert JR and Morgan ET (2001) Role of Nitric Oxide in Down-Regulation of CYP2B1 protein, but not RNA, in primary cultures of rat hepatocytes. Mol. Pharmacol. 60: 209-216.
Li-Masters T and Morgan ET (2002) Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from NO production by inducible nitric oxide synthase Biochem. Pharmacol. 64: 1703-1711.

Cheng P-Y, Wang M and Morgan ET (2003) Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcumin. J. Pharmacol. Exp. Ther. 307:1205-1212.

Kalsotra A, Cui X, Antonovic L, Robida AM, Morgan ET and Strobel HW (2003) Inflammatory prompts produce isoform-specific changes in the expression of leukotriene B4 ω-hydroxylases in rat liver and kidney. FEBS Lett. 555: 236-242.

Richardson TA and Morgan ET (2005) Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice. J. Pharmacol. Exp. Ther. 314: 703-709

Richardson TA, Sherman S, Antonovic L, Kardar SS, Strobel HW, Kalman D and Morgan ET (2006) Hepatic and renal cytochrome P450 gene regulation during Citrobacter rodentium infection in wildtype and toll-like receptor 4 mutant mice. Drug Metab. Dispos. 34: 354-360.

Richardson TA, Sherman S, Kalman D and Morgan ET (2006) Expression of UDP-glucuronosyltransferase mRNAs during inflammation and infection in mouse liver and kidney. Drug Metab. Dispos. 34: 351-353.

Aitken AE, Richardson TA and Morgan ET (2006) Regulation of Drug Metabolizing Enzymes and Transporters in Inflammation. Ann. Rev. Pharmacol. Toxicol., 46: 123-149.