7:45 am                 Registration/Continental breakfast

8:45 am                       Welcome remarks

                                                Richard Eglen – PerkinElmer Life & Analytical Sciences

                        Session 1:  Physical/Biophysical Studies:  Chair: Nigel Birdsall

9:00 am                      Muscarinic receptor structure and function: Mutatis mutandis

                                                Ed Hulme – MRC National Institute for Medical Research, London

9:45 am                       Muscarinic receptor dimers and clustering - single molecule studies on living cells

                                                Nigel Birdsall – MRC National Institute for Medical Research, London

10:30 am               Break

                        Session 2: Novel Aspects of Muscarinic Receptor Pharmacology:  Chair: Chris Felder

10:45 am                     At long last - emerging selective muscarinic receptor pharmacology

Christian Felder­ – Eli Lilly & Company, Indianapolis

11:30 am                     Potential for allosteric activators of M₁ and M₄ muscarinic receptors in the

                                    treatment of  schizophrenia

                                                Carrie Jones – Vanderbilt University

12:15 pm                     Optimizing inhaled muscarinic receptor antagonist dissociation rates to enhance duration and subtype selectivity

                                                Steven Charlton – Novartis, Horsham, UK

1:00 pm                Lunch  in Marriott Hall 3

2:00 pm                       Poster Session 1in Marriott Hall 3

                        Session 3: Muscarinic Receptor Signaling and Phenotypes:  Chair: Neil Nathanson   

3:15 pm                       Localization and trafficking of muscarinic acetylcholine receptors

                                                Neil Nathanson – University of Washington

4:00 pm                       Emerging data from novel muscarinic receptor mutant mouse models

                                                Jurgen Wess  –  NIDDK/NIH 

4.45 pm                Break

5:00 pm                       Subtype-specific functions of mAChRs revealed by the use of knockout mice

                                                Minoru Matsui – Chiba Institute of Science, Japan 

5:45 pm                       Muscarinic modulation of striatal physiology in health and disease
                                                James Surmeier – Northwestern University

6:30 pm                       Poster Session 2 in Marriott Hall 3

7:00 am               Continental breakfast

8:00 am                       Welcome remarks

                                                Richard Eglen – PerkinElmer Life & Analytical Sciences
 

                                  Session 4: Therapeutic Uses of Muscarinic Drugs:  Chair: Allison Fryer 
8:05 am                       Antimuscarinics and afferent signaling in the bladder
                                                Karl-Erik Andersson – Wake Forest University School of Medicine

8:50 am                       Muscarinic receptor agonists: A novel treatment for schizophrenia 

                                                Anantha Shekhar – Indiana University                

9:35 am                       Muscarinic antagonists and lung dysfunction
                                                  Allison Fryer – Oregon Health & Science University
 

10:20 am             Break
 

                            Plenary Lecture

10:35 am                     Structure and dynamics of the human β₂ adrenergic receptor 

                                                Brian Kobilka – Stanford University

                           Selected oral presentations from posters
11:20 am                      Use of acetylcholine nitrogen mustard to study allosteric interactions at the M1

                                    muscarinic receptor

                                               Katherine Figueroa – University of California, Irvine

11:35 am                      Differential effects on allosteric agonism and stimulus-trafficking by mutations in

                                     the orthosteric and allosteric pockets of M₂ muscarinic acetylcholine receptors

                                               Karen J. Gregory – Monash University

11:50 am                      Kinetic Analysis Of The M3-Ach-Receptor Activation In Living Cells
                                               Carsten Hoffmann – Universität Würzburg
12:05 pm                       Pharmacological characterisation of the M₃ muscarinic acetylcholine receptor
                                     in Saccharomyces cerevisiae

                                               Greg Stewart – Monash University

12:20 pm                      Muscarinic Receptors on Eosinophils Inhibit PAF-induced Eosinophil Activation
                                               Norah Verbout – Oregon Health & Science University

12:35 pm              Lunch in Marriott Hall 3

1:30 pm                Poster Session 3 in Marriott Hall 3

                           Session 5:  Emerging Areas and Novel Concepts:  Chair:  Richard Eglen

2:30 pm                       The muscarinic receptors in keratinocytes: Signaling pathways and biologic

                                    effects

                                                Sergei Grando – University of California, Irvine

3:15 pm                       Muscarinic receptors and apoptosis

                                                Andrew Tobin – University of Leicester, UK

4:00 pm               Break

4:15 pm             Otto Loewi New Investigator Award & Lecture
                                   Brain-specific deletion of M₃ muscarinic acetylcholine receptors causes pituitary

                                   hypoplasia and dwarfism in mice

                                                 Dinesh Gautam – NIDDK, NIH

5:00 pm                      Structure-function meets ligand-directed modeling:  Towards novel

                                   muscarinic receptor chemotypes

                                                Arthur Christopoulos – Monash University, Australia


5:30 pm            Presentation of the Ruth Levine Award Lecture

 

5:40 pm                       Closing Remarks       

                                        Nigel Birdsall – MRC National Institute for Medical Research, London
 

Print Program

ASPET Member Registration

Non Member Registration

Deadline Dates:                                                
      Registration with Abstract Submission to be Considered for:
             Poster Only                                            March 4, 2008 (closed)

             Otto Loewi Award                                  February 1 (closed)

             Ruth Levine Award                                February 1 (closed)

Poster Presentation Guidelines

Posters for this Colloquium will follow the guidelines set by EB 2008.  The poster-board surface area is 3'8" high and 5'6" wide. Prepare a 6" high headline strip that runs the full width of the poster. Include the title, authors, and affiliations on the strip in letters not less than 1" high. Post a large-typed copy of your abstract in the upper left-hand corner. 

For more information go to the EB  2008 website for presentation information:  http://www.eb2008.org/PosterPresentationGuidelines.htm

Poster Only

The deadline for submitting abstracts for posters has been extended to March 4, 2008.  Please email the abstracts to markin@aspet.org with a note indicating poster only for the Muscarinic Colloquium.  There are no font or formatting requirements, however, the abstract including title and authors should be no longer than 1620 characters. 

Awards for

New Investigators and Graduate Students Attending the

Recent Advances in Muscarinic Receptor Pharmacology Colloquium

Otto Loewi New Investigator Awards and Lectures

To recognize and encourage the work of young scientists, the Recent Advances in Muscarinic Receptor Pharmacology Colloquium will offer prizes to up to three (3) young investigators for scientific studies on muscarinic receptors.

Prizes:  $1,500  +  expenses

Eligibility:  Scientists of any nationality with postdoctoral experience of eight (8) years or less

Requirements: 

1.      Unpublished abstract in English submitted to the conference

2.      A description (less than 2,000 words) that highlights the novelty of the findings

3.      CV

4.      Lecture presentation at the conference

5.      All materials must be emailed to markin@aspet.org before February 1, 2008 with a note indicating the award.

Ruth Levine Award

To recognize Ruth Levine’s outstanding encouragement and promotion of the research of graduate and immediate postdoctoral scientists, the Recent Advances in Muscarinic Receptor Pharmacology Colloquium will offer the Ruth Levine Award.   Three (3) presenters will be selected by the Scientific Committee in advance of the meeting on the basis of their poster abstracts and they will be asked to present orally their most important findings, rather than the full content of their posters. The best presentation, based on both the oral and the poster, will be awarded the first Ruth Levine Award.

Prize:  $1,000

Eligibility:  Pre-doctoral or doctoral student or doctorate award less than 12 months before the date of the Symposium

Requirements:

1. Oral presentation at the conference of research that is substantially the presenter’s work

    2.   Abstract must be emailed to markin@aspet.org before February 1, 2008 with a note indicating the award.

Print Award Informtion
 

Ruth Levine Award