 |
|
|
 |
|
Recent Advances in Muscarinic Receptor Pharmacology and Therapeutics April 4-5, 2008 San Diego Marriott Hotel and Marina, San Diego, CA Organized By: Richard Eglen, Nigel Birdsall, Christian Felder, Allison Fryer and Neil Nathanson
Day 1 Friday, April 4
7:00 am Registration/Continental breakfast
8:45 am Welcome remarks Richard Eglen – PerkinElmer Life & Analytical Sciences
Session 1: Physical/Biophysical Studies: Chair: Nigel Birdsall 9:00 am M1 muscarinic receptors: Structure-function relationships Ed Hulme – MRC National Institute for Medical Research, London
9:45 am Muscarinic receptor dimers and clustering - single molecule studies on living cells Nigel Birdsall – MRC National Institute for Medical Research, London
10:30 am Break
Session 2: Novel Aspects of Muscarinic Receptor Pharmacology: Chair: Chris Felder 10:45 am At long last - emerging selective muscarinic receptor pharmacology Christian Felder – Eli Lilly & Company, Indianapolis
11:30 am Potential for allosteric activators of M1 and M4 muscarinic receptors in the treatment of schizophrenia Carrie Jones – Vanderbilt University
12:15 pm Optimizing inhaled muscarinic receptor antagonist dissociation rates to enhance duration and subtype selectivity Steven Charlton – Novartis, Horsham, UK
1:00 pm Lunch
2:00 pm Poster Session 1
Session 3: Muscarinic Receptor Signaling and Phenotypes: Chair: Neil Nathanson 3:15 pm Regulation of muscarinic receptor expression and function Neil Nathanson – University of Washington
4:00 pm Emerging data from transgenic models Jurgen Wess – NIDDK/NIH
4.45 pm Break
5:00 pm Subtype-specific functions of mAChRs revealed by the use of knockout mice Minoru Matsui – Dartmouth College
5:45 pm Muscarinic signaling in striatum TBD
6:30 pm Poster Session 2
Day 2 Saturday, April 5
7:45 am Continental breakfast
8:45 am Welcome remarks Richard Eglen – PerkinElmer Life & Analytical Sciences
Plenary Lecture 9:00 am Molecular and structural mechanisms of GPCR signaling Brian Kobilka – Stanford University
9.45 am Selected oral presentations from posters
10:45 am Break
Session 4: Therapeutic Uses of Muscarinic Drugs: Chair: Allison Fryer 11.00 am Muscarinic receptor agonists: a novel treatment for schizophrenia Anantha Shekhar – Indiana University
11.45 am Muscarinic antagonists and urinary tract dysfunction TBD
12:30 pm Muscarinic antagonists and lung dysfunction Allison Fryer – Oregon Health & Science University
1:15 pm Lunch
2:15 pm Poster Session 3
Session 5: Emerging Areas and Novel Concepts: Chair: Richard Eglen 3:30 pm Non neuronal muscarinic systems Sergei Grando – University of California, Irvine
4.15 pm Muscarinic receptors and apoptosis Andrew Tobin – University of Leicester, UK
5.00 pm Break
5.15 pm
Otto Loewi New Investigator Award
& Lecture
6.00 pm Emerging news in muscarinic area TBD
6.15 pm Ruth Levine Award Lecture TBD
6:25 pm Closing Remarks
Nigel Birdsall
– MRC National
Institute for Medical Research, London
|