Norman Weiner Lecture

Structural Basis for Function and Pharmacology of Voltage-Gated Sodium and Calcium Channels

Speaker: William Catterall—University of Washington

Boston Convention & Exhibition Center
Wednesday, April 01, 2015
8:30 am–9:20 am

About the Speaker

William CatterralDr. William A. Catterall received his bachelor's degree in chemistry from Brown University in 1968, his doctoral degree in physiological chemistry from Johns Hopkins School of Medicine in 1972, and his postdoctoral training in neurobiology and molecular pharmacology as a Muscular Dystrophy Association Research Fellow with Dr. Marshall Nirenberg at the National Institutes of Health from 1972 to 1974. Following three more years as a staff scientist at the National Institutes of Health, he joined the faculty of the University of Washington School of Medicine in 1977 as an associate professor in the Department of Pharmacology, became professor in 1981, and chair of the Department of Pharmacology in 1984.

After establishing his laboratory at the University of Washington, Dr. Catterall and his colleagues discovered the voltage-gated sodium and calcium channel proteins, which are responsible for generation of electrical signals in the brain, heart, skeletal muscles, and other excitable cells. Their subsequent work has contributed much to understanding the structure, function, regulation, and molecular pharmacology of these key cell-signaling molecules. Dr. Catterall's recent work has turned toward understanding diseases caused by impaired function and regulation of voltage-gated ion channels, including epilepsy and periodic paralysis.

He served as editor-in-chief of Molecular Pharmacology from 1985 to 1990, was a founding member of the editorial board of Neuron in 1988, and has been an editorial board member of numerous other professional journals. Dr. Catterall and his colleagues have published more than 400 research papers and 30 reviews and reference works on voltage-gated ion channels. Catterall is a member of several science academies, including the US National Academy of Science, the Institute of Medicine, and the Royal Society of London, UK. He has received numerous awards, including the Gairdner International Award of Canada in 2010.

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