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JPET Highlight: GPR35 Antagonists Display High Species Ortholog Selectivity

Posted on 11/15/2012 5:32:08 PM

Substantial selectivity in potency of a number of GPR35 agonists has previously been demonstrated between human and rat orthologs of this G protein coupled receptor. This study demonstrated that there is also species selectivity with GPR35 antagonists, further demonstrating that care is required when exploring the function of GPR35 across species. See article at J Pharmacol Exp Ther 2012 343:683–695. (JPET 198945)

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