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Journal Highlights

DMD Highlight: Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics

Posted on 11/17/2016 1:39:00 PM

DMD December Highlights Prasad et al 

Although progress is being made, current cell culture models do not allow the accurate prediction of the contribution of renal secretion and renal cellular accumulation to disposition of drugs during the drug development process.  The determination in this paper by Prasad et al of the absolute abundances of the most important drug transporters in human kidney provides vital information to allow the extrapolation of in vitro findings to the in vivo situation.  Significant correlations were found between the expression levels of various transporters, notably OAT1 and OAT3, supporting common mechanisms of regulation.

See the article by Prasad et al. at Drug Metabolism and Disposition December 2016, 44 (12) 1920-1924; DOI: http://dx.doi.org/10.1124/dmd.116.072066 

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