-Member Login

Forgot your USERNAME OR PASSWORD?

Job Postings

Let's Stay Connected

Find us on the popular social networks

Facebook Twitter LinkedIn Flicker

Journal Highlights

MOL Highlight: Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism

Posted on 2/23/2017 4:11:37 PM

MOL Feb Highlights Audet-Delage et al 

Audet-Delage et al. demonstrate that an alternatively spliced form of human glucuronosyltransferase 1, known to control glucuronidation activity via protein-protein interactions, also functionally interacts with key enzymes in metabolic pathways co-opted by cancer. One such target is the rate-limiting enzyme of glycolysis, pyruvate kinase. Depletion of the splice variant enforces the Warburg effect (a high glycolytic rate at the expense of mitochondrial respiration needed to fuel the activities of cancer cells) and leads to lactate accumulation. Many metabolites derived from the glycolytic and tricarboxylic acid cycle pathways were affected in a manner consistent with greater metastatic potential by the selective down-regulation of the splice variant in colon tumors. Glucuronosyltransferase 1 splice variants may thus be part of an expanding number of metabolic pathways known to be involved in contributing to the oncogenic phenotype of colon cancer cells.

See the article by Audet-Delage et al. at Molecular Pharmacology March 2017, 91 (3) 167-177; DOI: https://doi.org/10.1124/mol.116.106161 

Comments (0)


Leave a comment


Blog comments are moderated and will be posted once approved.

Name


Comment:


Enter the code shown below:

Recent Posts

Archive

.

Hot Links 

EB2017 

Join ASPET 

What is Pharmacology? Video 

PharmTalk Blog