DMD Highlight: Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism
From queries of several NIH databases, Annalora and colleagues found nearly 1000 distinct mRNA transcripts produced by the 57 human cytochrome P450 genes, suggesting that alternative splicing is under-appreciated for its roles in P450 diversity, human health and diseases. This review focuses on emergent aspects of the adaptive gene-splicing process, which when viewed through the lens of P450–nuclear receptor gene interactions, resembles a primitive immune-like system that can rapidly monitor, respond, and diversify to acclimate to fluctuations in endo-xenobiotic exposure.
See the article by Annalora et al. at Drug Metabolism and Disposition April 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254