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Journal Highlights

MOL Highlight: Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells

Posted on 5/5/2017 1:31:15 PM

MOL May Highlights Stallaert et al
 

By depleting the heterotrimeric G protein Gs in human embryonic kidney cells using the CRISPR/Cas9 system, the authors reveal a Gs-dependent but cAMP-independent increase in intracellular Ca2+ following β2AR stimulation. Subsequent pharmacological studies indicate that this increase is initiated by Gs-dependent release of ATP, which transactivates Gq-coupled P2Y receptors through an inside-out mechanism and leads to a Gq- and IP3-dependent Ca2+ mobilization from intracellular stores. Given that β2AR and P2Y receptors are co-expressed in various tissues, this signaling paradigm could be physiologically important and have therapeutic implications.

See the article by Stallaert et al. at Molecular Pharmacology May 2017, 91 (5) 533-544; DOI: https://doi.org/10.1124/mol.116.106419 

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