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Journal Highlights

MOL Highlight: Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia

Posted on 5/5/2017 1:33:17 PM

MOL May Highlights Yueh et al

Although neonatal jaundice is mostly benign, extremely high levels of serum bilirubin can cause neurologic dysfunction, potentially leading to permanent brain damage. A large portion of hyperbilirubinemia cases in newborns are associated with hemolytic diseases, but the impaired ability of UDP- glucuronosyltransferase to eliminate bilirubin contributes to hyperbilirubinemia-induced neurotoxicity in early developmental stages. This review summarizes the progress that has been made in recent years towards understanding the causes and physiopathology of severe hyperbilirubinemia and the molecular mechanisms underlying bilirubin-induced encephalopathy, identifying environmental factors that alleviate of worsen the condition, and developing therapies for treating pathologic hyperbilirubinemia.

See the article by Yueh et al. at Molecular Pharmacology May 2017, 91 (5) 545-553; DOI: https://doi.org/10.1124/mol.116.107524 

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