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Journal Highlights

DMD Highlight: Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate

Posted on 7/18/2017 3:36:32 PM

DMD August Highlights Shen et al 

Reliable endogenous biomarkers for drug transporter function are desirable for detection and risk stratification of transporter-mediated drug-drug interactions (DDIs).  In a clinical DDI study, Shen et al found that hexadecanedioate (HDA) and tetradecanedioate (TDA), but not bile acids, correlated with changes in rosuvastatin pharmacokinetics after administration of an organic anion transporting polypeptide (OATP) inhibitor humans, suggesting that HDA and TDA are useful for OATP functional assessment, either alone or in combination with the previously discovered biomarkers Coproporphyrins I and III.

See the article by Shen et al. at Drug Metabolism and Disposition August 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531 

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