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James R. Gillette Award

Award Description | Presentation | Nomination Criteria and Process | Prior Recipients

Award Description

The James R. Gillette Award is presented each year for two outstanding papers published in Drug Metabolism and Disposition, one each in the broad categories of a) Drug Metabolism and b) Disposition and Pharmacokinetics.

Presentation

The award is presented annually. The award consists of:

Invitation to the first author to present the work at a platform session at the annual meeting
Travel support and complimentary registration at the annual meeting
Cash award of $250 for the first author

Nomination Criteria and Process

All manuscripts published in Drug Metabolism and Disposition (DMD) in a given calendar year are eligible. After the last issue of the year has closed, the DMD editor provides a list of the nominated manuscripts to the Drug Metabolism and Disposition Division.

Selections are made based on the primary review of the manuscript for publication, followed by a secondary review by the James R. Gillette Best Paper Award Committee. The Award Committee consists of members of the executive committee, is chaired by the Division for Drug Metabolism and Disposition’s Past-Chair, and may include outside expertise as necessary. Award winners are selected at the end of the calendar year, and notified in January or February. Current division chairs and secretary/treasurers and the ASPET Council president and secretary/treasurer are ineligible for division awards during their active tenure.

Award Recipients

2021

Metabolism category: Co-first authors Shida Qiao from the Chinese Academy of Sciences and the University of Chinese Academy of Sciences and Sisi Feng from Shanghai Hexaell Biotech Co., Ltd. for the paper titled “Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity.”

Pharmacokinetics/Drug Transporters category: Sara Shum from the University of Washington for the paper titled "Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling"

2020

Metabolism category: Bridget L. Morse, PharmD, PhD from Eli Lilly and Company for the paper titled "Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake."

Pharmacokinetics/Drug Transporters category: Eva Hansmann for work done while at the Laboratory of Environmental Toxicology, Department of Pharmacology at the University of California, San Diego for the paper titled "Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice”

2019

Metabolism category: Dr. Drew R. Neavin received the award for "Single Nucleotide Polymorphisms at a Distance from Aryl Hydrocarbon Receptor (AHR) Binding Sites Influence AHR Ligand–Dependent Gene Expression." Drug Metabolism and Disposition, September 2019, 47 (9) 983-994; DOI: https://doi.org/10.1124/dmd.119.087312

Pharmacokinetics/Drug Transporters category: Dr. Takeshi Miyake received the award for "Elucidation of N1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters." Drug Metabolism and Disposition, November 2019, 47 (11) 1270-1280; DOI: https://doi.org/10.1124/dmd.119.087262

2018

Metabolism category: Dr. Carsten Ginsel received the award for “The Involvement of the Mitochondrial Amidoxime Reducing Component (mARC) in the Reductive Metabolism of Hydroxamic Acids.” Drug Metabolism and Disposition, October 2018, 46 (10) 1396-1402; DOI: https://doi.org/10.1124/dmd.118.082453

Pharmacokinetics/Drug Transporters category: Dr. Hong Shen received the award for “Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.” Drug Metabolism and Disposition, February 2018, 46 (2) 178-188; DOI: https://doi.org/10.1124/dmd.117.077586

2017

Drug Metabolism category: Dr. Casey Dorr accepted the award for " CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism." Drug Metabolism and Disposition, August 2017;45(8):957-965; DOI: https://doi.org/10.1124/dmd.117.076307.

Pharmacokinetics/Drug Transporters category: Dr. Marilyn Giacomini accepted the award for " Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters." Drug Metabolism and Disposition, January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338.

2016

Drug Metabolism category: Dr. Miho Kazui accepted the award for “Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase.” Drug Metabolism and Disposition, January 2016, 44 (1) 115-123; DOI: https://doi.org/10.1124/dmd.115.066290.

Pharmacokinetics/Drug Transporters category: Dr. Edwin C. Y. Chow accepted the award for “Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiological Spaces, and Hepatic Enzymes and Transporters.” Drug Metabolism and Disposition, September 2016, 44 (9) 1524-1535; DOI: https://doi.org/10.1124/dmd.116.070060.

2015

Drug Metabolism category: Yun-Chen Tien accepted the award “Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver.” Drug Metabolism Disposition, December 2015, 43:1938-1945. Dr. Tien’s paper was presented by Xiaobo Zhong.

Pharmacokinetics/Drug Transporters category: Li Liu accepted the award “Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study.” Drug Metabolism Disposition, November 2015, 43:1795-1804. Dr. Liu’s paper was presented by Jashvant Unadkat.

2014

Drug Metabolism category: Kunzhi Jia accepted the award “Generation and Characterization of a Novel CYP2A13-Transgenic Mouse Model.” Drug Metabolism Disposition, August 2014, 42:1341-1348. Dr. Jia’s paper was presented by Xinxin Ding.

Pharmacokinetics/Drug Transporters category: Toru Takenaka accepted the award “Human Small Intestinal Epithelial Cells Differentiated from Adult Intestinal Stem Cells as a Novel System for Predicting Oral Drug Absorption in Humans.” Drug Metabolism Disposition, November 2014, 42:1947-1954.

2013

Drug Metabolism category: Amarjit S. Chaudhry accepted the award “Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s.” Drug Metabolism Disposition, August 2013, 41:1538-1547.

Pharmacokinetics/Drug Transporters category: Toshiyuki Kudo accepted the award “Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic update transporter and metabolic enzymes.” Drug Metabolism Disposition, February 2013, 41:362-371.

2012

Drug Metabolism category: Manabu Matsunawa “Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages.” Drug Metabolism Disposition, November 2012, 40:2059-2066. Dr. Matsunawa’s paper was presented by Shigeyuki Uno.

Pharmacokinetics/Drug Transporters category: Hamsell M. Alvarez accepted the award “Effects of PEGylation and Immune Complex Formation on the Pharmacokinetics and Biodistribution of Recombinant Interleukin 10 in Mice.” Drug Metabolism Disposition, February 2012, 40:360-373.

2011

Drug Metabolism category: Kyoung Noh accepted the award “Farnesoid X Receptor Activation by Chenodeoxycholic Acid Induces Detoxifying Enzymes through AMP-Activated Protein Kinase and Extracellular Signal-Regulated Kinase 1/2-Mediated Phosphorylation of CCAAT/Enhancer Binding Protein β.” Drug Metabolism Disposition, August 2011, 39:1451-1459.

Pharmacokinetics/Drug Transporters category: Xuena Lin accepted the award “Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using a Caco-2 Model.” Drug Metabolism Disposition, February 2011, 39:265-274.

2010

Drug Metabolism category: Fang Li accepted the award “Ecto-5'-Nucleotidase and Thiopurine Cellular Circulation: Association with Cytotoxicity.” Drug Metabolism Disposition, December 2010, 38:2329-2338.

Pharmacokinetics/Drug Transporters category: Tomoya Yasujima accepted the award “Evaluation of 4',6-Diamidino-2-phenylindole as a Fluorescent Probe Substrate for Rapid Assays of the Functionality of Human Multidrug and Toxin Extrusion Proteins.” Drug Metabolism Disposition, April 2010, 38:715-721.

2009

Drug Metabolism category: Natasha DeVore accepted the award “Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes.” Drug Metabolism Disposition, June 2009, 37:1319-1327.

Pharmacokinetics/Drug Transporters category: Katharine Howe accepted the award “In Silico and in Vitro Modeling of Hepatocyte Drug Transport Processes: Importance of ABCC2 Expression Levels in the Disposition of Carboxydichlorofluroscein.” Drug Metabolism Disposition, February 2009, 37:391-399.