In This Section

G Proteins and G Protein Coupled Receptors in Cancer

Monday April 23, 2018

9:30 am - 12:00 pm

Room 16B
Sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Cancer Pharmacology (DCP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Translational and Clinical Pharmacology (TCP)

Chair :

Paul Insel
University of California, San Diego

J. Silvio Gutkind
University of California, San Diego


GPCRs, the largest family of cell surface signaling proteins and the targets for >30% of FDA-approved drugs, play key physiological and pathophysiological roles, in part through their activation of heterotrimeric G proteins. Recent analyses of human cancer genomes revealed an unanticipated high frequency of mutations in G proteins and GPCRs in many tumor types, including the discovery of mutant GPCRs and G proteins as driver oncogenes. GPCRs also regulate tumor-induced angiogenesis, cancer stem cell maintenance, metastasis, and immune evasion of cancer. Speakers in this symposium will describe efforts to translate such recent knowledge into new pharmacological interventions for cancer prevention and treatment.

Viral Hijacking of GPCR Networks in Cancer
Martine Smit - Vrije Universiteit Amsterdam

G Protein Regulation of Glioblastoma Stem Cells
Joan Heller Brown - University of California, San Diego

The Human Onco-GPCRome: Opportunities for Cancer Prevention and Treatment
J. Silvio Gutkind - University of California, San Diego

Clinical Activity Novel GPCR Targeting Agents in Cancer: An Industry Perspective
Joshua Allen - Oncoceutics, Inc

A Novel BRET Biosensor for Gαq-GTP Reveals Unique Properties of Cancer-associated GNAQ Mutants
Mikel Garcia-Marcos - Boston University

HRH1: A Novel GPCR Drug Target in Pancreatic Cancer
Alyssa Rodriguez - University of California, San Diego

Thank you to our Annual Meeting partners:

UCI Pharmacology
UT Health San Antonio
University of Minnesota
University of Michigan Pharmacology
University of Wisconsin
Wake Forest University
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West_Virginia_University 
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