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G protein-β-arrestin Interplay: Molecular and Therapeutic Implications

Sunday April 07, 2019

8:00 am - 10:00 am

Room W205 BC
Sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Translational and Clinical Pharmacology (TCP)

Chair :

Douglas Tilley
Temple Univ School of Medicine

Yang Xiang
University of California at Davis

GPCRs proximally engage G proteins and β-arrestins to relay various effects at the receptor, cellular and physiologic levels. Recent drug discovery efforts have focused on the preferential engagement of either G proteins or β-arrestins to exert specific signaling outcomes. However, several studies have begun to highlight the complex interplay between G proteins and β-arrestins that complicate our understanding of these signaling paradigms. Thus, this session will highlight the latest concepts with regard to the ligand bias and the molecular relationship between G proteins and β-arrestins, as well as their application to relevant cell types and desired therapeutic outcomes.

Structural Insights Into G protein and β-arrestin Interplay at the Receptor
Arun Shukla - Indian Institute of Technology Kanpur

Upstream-Downstream-Parallel: A Fresh Perspective on Hierarchies of GPCR Transducers
Evi Kostenis - University of Bonn

β-arrestin-independent G Protein Signaling
J. Silvio Gutkind - Univ of California, San Diego

Ligand Bias and Therapeutic Efficacy
Laura Bohn - The Scripps Research Institute

Negative Allosteric Modulation of Arrestin Recruitment to the β2-Adrenergic Receptor
Michael Ippolito - Thomas Jefferson University

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology