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Behavioral Pharmacology of Biased Agonists

Sunday April 05, 2020

3:00 pm - 5:00 pm

Room 17 A
Co-sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Neuropharmacology (NEU)

Chair :

William Fantegrossi
University of Arkansas for Medical Sciences

Development of “biased ligands” preferentially activating specific signaling pathways by stabilizing subsets of receptor conformations that invoke distinct G protein-dependent or –independent signaling are underway. Development of novel analgesics acting via CB1, μ-, δ- and κ-opioid receptors is focused on identification of G protein-selective compounds that are devoid of β-arrestin 2 recruitment because evidence suggests that this may reduce adverse effects. Results of these efforts appear promising in vitro, but in vivo confirmation of biased agonism is relatively rare. This symposium will survey biased agonism across pharmacological classes, focusing on behavioral effects which may differentiate them from traditional unbiased agonists.

In vivo Evaluation of G Protein Biased Agonists at Mu-opioid Receptors in Non-human Primates
Mei-Chuan (Holden) Ko - Wake Forest University

Characterization of Structurally Novel G Protein Biased CB1 Agonists
Paul Prather - University of Arkansas for Medical Sciences

Biased Agonism at Beta-1 Adrenergic Receptors as a Novel Treatment Strategy for Alzheimer's Disease
Mehrdad Shamloo - Stanford University School of Medicine

Functional Selectivity at the Serotonin 5-HT2A Receptor
Charles Nichols - LSU New Orleans

Last Updated: November 8, 2019
Key Dates
March 6

Housing discounts end

March 13

Advance Registration Ends

April 3-4

GPCR Colloquium (separate ticket required)

April 4

ASPET Business Meeting and Awards Presentation

April 4-7

ASPET Annual Meeting at EB 2020

Thank you to our Annual Meeting partners:

University of Kentucky
Icahn School
University of Georgia
University of Minnesota
WSU Pharm-Pharm Sciences Unit
PR & P