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The Use of Chemogenetic Tools to Analyze Behavior in Non-human Primates

Monday April 06, 2020

8:00 am - 10:00 am

Room 17 A
Sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Neuropharmacology (NEU)

Chair :

Kathleen Grant
Oregon National Primate Research Center (ONPRC)

Verginia Cuzon Carlson
Oregon National Primate Research Center, Oregon Health & Sciences University

The in vivo manipulation of specific brain regions is invaluable for unraveling the circuitry bases of human complex behaviors and disease states. Non-human primates (NHP), like the macaque, are a favorable animal model due to their human homology in cortical expansion sub serving prefrontal associative functions, fine motor control, social context, and physiology. Here, we describe the use of state-of-the-art chemogenetic constructs in awake-behaving NHPs. We also discuss validation methods being developed for non-invasive imaging of viral targeting and expression focusing on PET/fMRI in NHPs.

Querying the Role Of the Putamen in Cognitive Flexibility and Alcohol Drinking in Rhesus Macaques Using DREADDs
Verginia Cuzon Carlson - Oregon National Primate Research Center, Oregon Health & Sciences University

Chemogenetic Modulation of the Nucleus Accumbens in Ethanol Discrimination
Daicia Allen - University of California Los Angeles

Development of the Chemogenetic Toolset PSAM/PSEM for Use in Non-human Primates
Jessica Raper - Yerkes National Primate Research Center, Emory University

PET-imaging Guided Chemogenetics Dissects Frontal-subcortical Circuits in Monkeys
Takafumi Minamimoto - National Institutes for Quantum and Radiological Science and Technology

Last Updated: November 8, 2019
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March 13

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April 3-4

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April 4

ASPET Business Meeting and Awards Presentation

April 4-7

ASPET Annual Meeting at EB 2020

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