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Yin-Yang of the Prostaglandin-E2 Receptors: Novel Therapeutic Approaches

Saturday April 04, 2020

11:00 am - 1:00 pm

Room 17 A
Sponsored by the Division for Neuropharmacology (NEU)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Molecular Pharmacology (MP)

Chair :

Thota Ganesh
Emory University

Prostaglandin-E2 receptors (EP1, EP2, EP3, P4) have emerged as very important biological targets with a variety of beneficial and deleterious functions during the development of a several peripheral and central nervous system diseases, via intracellular cAMP and Ca+2 signaling molecules. Several laboratories have been investigating the “yin-yang” roles of these receptors in physiology and neurodegenerative pathology and gliomas. This symposium will summarize the current developments in the field using genetic animal models, and small molecule modulators of these receptors indicating whether targeting these receptors will be a better strategy than traditional COX-2 inhibition, which led to adverse cardiotoxicity in human.

Lessons Learned from COX-2 Drugs: Targeting Downstream COX-2 Signaling for Drug Discovery
Tilo Grosser - University of Pennsylvania

Yin-Yang of PGE2 Receptors in CNS Disorders
Katrin Andreasson - Stanford University School of Medicine

Targeting Proinflammatory Prostaglandin Receptors for Malignant Gliomas
Jianxiong Jiang - University of Tennessee Health Science Center

Discovery and Poor-of-Concept Studies of EP2 Antagonists in Neurodegenerative Disease Models
Thota Ganesh - Emory University

Last Updated: November 8, 2019
Key Dates
March 6

Housing discounts end

March 13

Advance Registration Ends

April 3-4

GPCR Colloquium (separate ticket required)

April 4

ASPET Business Meeting and Awards Presentation

April 4-7

ASPET Annual Meeting at EB 2020

Thank you to our Annual Meeting partners:

University of Kentucky
Icahn School
University of Georgia
University of Minnesota
WSU Pharm-Pharm Sciences Unit
PR & P