Siennah Miller is the Molecular Pharmacology Highlighted Trainee Author for the February 2021 issue. Ms. Miller is currently a fourth year PhD candidate at the University of Arizona College of Pharmacy. Her mentor is Dr. Nathan J. Cherrington. The Molecular Pharmacology article that earned her selection as a Highlighted Trainee Author is titled "Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling" and is available at DOI: https://doi.org/10.1124/molpharm.120.000169
Ms. Miller is currently collaborating with Collaborations Pharmaceuticals, Inc. on developing pharmacophores for equilibrative nucleoside transporters. Computational models of drug-transporter interactions can be incredibly informative during the drug discovery and development process. She is also in the process of identifying other therapeutic agents that can cross the blood-testis barrier using transporters and validating this in animal models.
The anticipated impact of Ms. Miller’s current research is on improving drug disposition to the testis, a “sanctuary site” that is an area of the body where viral infections and cancer can evade treatment. Drugs that can cross the blood-testis barrier have the potential to treat diseases more effectively, reduce the likelihood of viral transmission from semen, and decrease the need for irradiation/orchiectomy resulting in loss of fertility. Since transporters play an important role in drug disposition to the testis, it is important to identify drugs that cross this barrier and to develop computational models that can inform and guide decisions regarding new and existing therapies.
Outside the lab, Siennah likes to hike, bake, and travel.