Victoria Saca is the Molecular Pharmacology Highlighted Trainee Author for March 2025. Victoria is a 5th year PhD student in Tom Sakmar’s Lab at Rockefeller University and a member of the Tri-Institutional PhD Program in Chemical Biology. 

The DMD article that earned her the selection as a Highlighted Trainee Author is titled “G protein-coupled receptor–targeted proteolysis-targeting chimeras in cancer therapeutics” and is available at: https://doi.org/10.1016/j.molpha.2024.100013.  

“I hope that my research helps to further expand the use of PROTAC technology to target GPCRs and other membrane proteins. Although targeted protein degradation methods (TPD) have been applied to a few GPCRs, my work suggests that TPD methods might be useful more broadly to suppress constitutively active GPCRs, for example.”