The symposium will highlight the current progress on cell-cell communications involved in the development of heart failure and preclinical treatment. Heart failure is a complicated process that is involved interactions among myocytes, fibroblasts, endothelia cells, pericytes, adipocytes, and marcophages, etc, and critical to understand the tissue remodeling underlying a variety of cardiac phenotypes, ranging from depressed ejection fraction, impaired cardiac relaxation, to cardiac arrhythmia. The symposium aims to deliver the important messengers to better understand non-traditional mechanisms of cell-cell communication in heart failure.