Program

New Session Detail

Evolution of Psychedelics: Molecules Inspired by 5-HT2 Receptor Biology

Friday May 19, 2023

10:30 am - 12:00 pm Central Time (CT)





Chair :

Kathryn Cunningham
University of Texas Medical Branch

Kurt Rasmussen
Delix Therapeutics



Psychedelics hold great promise for the treatment of several neuropsychiatric disorders. These compounds induce rapid and long-lasting neuroplastic effects in cortical neurons, effects which may play an important role in their therapeutic efficacy. The potential therapeutic impact of resetting neuroplasticity is linked to their affinity/efficacy for the serotonin 5-HT2A receptor (5-HT2AR). Unfortunately, hallucinogenic drugs may not be a viable option for many patients as even mild dementia or a history of psychosis may heighten risk for drug-associated adverse effects. There is a critical chemical gap in the development of molecules that maintain the neuroplasticity-promoting effects of psychedelics, but with a range of hallucinogenic-like effects. New classes of compounds have been synthesized that hold promise as non-hallucinogenic 5-HT2AR potentiators and therapeutics, and this panel presents distinct and innovative approaches in this regard.

Speakers

Kathryn Cunningham - University of Texas Medical Branch

Kurt Rasmussen - Delix Therapeutics

Psychedelics ≠ Hallucinogens: An Overview of Questions in the Field

Kathryn Cunningham - University of Texas Medical Branch

Positive Allosteric Modulators to Enhance 5-HT2C and 5-HT2A Receptors Functionality

Lindsay Cameron - University of California, Davis

The Development of Tabernanthalog: A Non-Hallucinogenic Psychoplastogen

Charles Nichols - LSU Health Sciences Center

New Chemical Entities Derived from Psychedelics: Dissecting Anti-Inflammatory vs. Behavioral Efficacy

Joshua Zamora - University of Texas Medical Branch

Modulation of 5-HT2A Receptor Functional Efficacy Via Protein: Protein Interactions

Kurt Rasmussen - Delix Therapeutics

Conclusion

ASPET 2023 Annual Meeting Program
Important Dates

Apr

20

Registration Discounts End

Apr

14-24

Division Town Halls

Apr

24

Housing Deadline

May

3-10

Online Award Lecture Series

May

18-21

ASPET 2023 Annual Meeting
St. Louis Union Station, MO

1801 Rockville Pike, Suite 210, Rockville, Maryland 20852-1633
Phone: (301) 634-7060
Fax: (301) 634-7061   aspet.org
Meeting Questions

Visit us on Facebook Twitter LinkedIn
© 2023 American Society for Pharmacology and Experimental Therapeutics