Dr. William Kaelin is the Sidney Farber Professor of Medicine at Harvard Medical School and Dana-Farber Cancer Institute, Senior Physician in Medicine at Brigham and Women's Hospital and Howard Hughes Medical Institute Investigator. A Nobel Laureate, Dr. Kaelin received the 2019 Nobel Prize in Physiology or Medicine. Dr. Kaelin's research seeks to understand how, mechanistically, mutations affecting tumor-suppressor genes cause cancer. His laboratory is currently focused on studies of the VHL, RB-1, and p53 biochemical functions of tumor suppressor genes. The team uses genetic and biochemical approaches with both human and mouse cells, including genetically engineered mouse models. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the National Academy of Medicine, the American Society of Clinical Investigation, and the American College of Physicians.