Heart failure is a major cause of morbidity and mortality in older adults, representing the main cause of hospitalization in this population. However, effective pharmacological intervention for this disease is lacking. This session will discuss recent advances in understanding molecular mechanisms of cardiac aging and their potential therapeutic implications for aged-related cardiac disease. Three leading investigators and two trainees will discuss how stress drives cardiac aging, how to target brown adipose tissue to treat cardiac senescence, and how to target aging hallmarks to treat heart failure with preserved ejection fration, the most common form of heart failure in older adults.