Throughout history plant extracts have had a considerable role in human health and even today plant-derived remedies are often used as alternative medicines. Many natural products have actions consistent with ion channel modulation and sophisticated electrophysiology, mutagenesis and molecular modelling has revealed how certain plant extracts modify ion channel activity. The work on temperature and mechanosensitive ion channels modulation by chilli extract, menthol or garlic derived pungents by the 2021 Nobel prize winners for Physiology/Medicine, David Julius and Ardem Patapoutian, brings considerable focus to this aspect of pharmacology. The proposed symposium features speakers who will describe different facets of ion channel modulation by plant-derived entities. Derivation of key molecular hot spots for plant derived products provides considerable insight into the workings of several ion channels with key physiological roles. The symposium will be of broad appeal for members with interests in ion channel modulation, pharmacophore modelling, pharmacological translation and drug targeting.