In recent years, extensive studies implicated myeloid cells in tumor development, progression and metastasis. Myeloid cells is a complex network of different cells with different function. These cells are characterized by fascinating biology and biochemistry and focus of intensive studies by many research groups in academia and multiple pharmaceutical companies. Clinical studies support their role in tumor progression and limitation of the effect of various immune therapeutics. Because of this, there is an intensive effort to target this cells. The session will cover the role and targeting opportunities for myeloid-derived suppressor cells and macrophages in different types of cancer.  The goal of this session is to discuss several topics focused on different aspects of myeloid cell biology and their targeting.