G protein-coupled receptor (GPCR) signal transduction is involved in virtually all aspects of human physiology, and its dysregulation gives rise to many neurological, metabolic, and cardiovascular diseases as well as cancer. Accordingly, GPCRs are the targets of ~33% of clinically used medications. This ASPET colloquium will highlight recent breakthroughs in understanding GPCR signaling mechanisms and their implications for human health and drug development.
Join us for this all-day satellite event on Wednesday, May 20 at the Hyatt Regency Minneapolis, held in conjunction with the ASPET 2026 Annual Meeting. Extra-fees apply.
Note: The morning program runs concurrently with the ASPET Annual Meeting.
9:15 am – 9:30 am
Welcome and Introductory Remarks by the Organizing Committee
9:30 am - 10:15 am
Keynote: Jeff Benovic Thomas Jefferson University, Professor Dissecting the Role of GRKs and Arrestins in GPCR Signaling
10:15 am – 10:45 am
Coffee Break / Networking
10:45 am – 12:15 pm
Session 1: Molecular, Cellular, and Spatial Dynamics of GPCR Signaling
10:45 am – 11:05 am Vselvolod (Seva) Gurevich Vanderbilt University, Professor Deceptive Beauty of Arrestin Structures
11:05 am – 11:25 am Makaia Papasergi-Scott University of Rochester, Assistant Professor Time-resolved Cryo-EM of G Protein Activation
11:25 am – 11:45 pm Alan Smrcka University of Michigan, Professor G Protein/PLC Signaling Nanodomains in Heart Failure
11:45 pm – 12:05 pm Roshanak Irannejad University of California San Francisco, Associate Professor Monoamine Transporters and Intracellular GPCR Signaling
12:05 pm – 12:15 pm Madelyn MooreUniversity of MinnesotaTailoring β-arrestin Potency of Intracellular NTSR1 Ligands via NTSR1-GRK2 Structure-guided Design
12:15 pm – 12:30 pm
Networking in the Colloquium room with speakers/ attendees prior to lunch
12:30 pm – 2:30 pm
COLLOQUIUM PAUSES. GUESTS ATTEND ANNUAL MEETING AWARD LUNCH
2:30 pm – 4:00 pm
Session 2: Structure-Based Drug Discovery
2:30 pm – 2:50 pm JoAnn Trejo University of California San Diego, Professor Signaling Bias of the Protease-activated Receptor-1 Drives Beta-arrestin-2-mediated Endothelial Cytoprotection
2:50 pm – 3:10 pm Adriano Marchese Medical College of Wisconsin, Professor Arrestin-dependent and Independent GPCR Trafficking and Signaling
3:10 pm – 3:30 pm John Tesmer Purdue University, Professor Activation and Selective Inhibition of G Protein-Coupled Receptor Kinases
3:30 pm – 3:50 pm Nina Tsvetanova Duke University, Assistant Professor GPCR Signaling from Endomembranes
3:50 pm – 4:00 pm Yasmin AydinIndiana University School of MedicineLipid Environment and Phosphorylation Barcode Synergistically Shape Arrestin-2 Activation
4:00 pm – 4:45 pm
Keynote: Mark Von Zastrow University of California San Francisco, Professor Functional Specialization of GPCR Signaling by β-arrestins
4:45 pm – 6:30 pm
Poster Session – Networking - Mixer
6:30 pm
Colloquium adjourns (dinner on own)
Abstract submission deadline: December 4, 2025 Poster presenters for the colloquium will be selected from abstracts submitted by December 4 to ASPET Annual Meeting specifically within the GPCR topic category (#3.6-GPCR). Accepted posters will be presented at both the colloquium on Wednesday, May 20 and scheduled to present during one of the main ASPET Annual Meeting poster sessions on Sunday-Tuesday, May 17-19.
This is a satellite meeting to ASPET Annual Meeting. The colloquium ticket fee will be in addition to your Annual Meeting registration fees. Register here.
Contact ASPET Meetings with questions.
Sponsorship offers your organization the opportunity to stand out as a leader, gain visibility with an engaged scientific audience, and demonstrate your support for advancing discovery and innovation. Sponsors benefit from brand recognition across multiple channels, direct connections with attendees, and exclusive opportunities that showcase your expertise and commitment to the scientific community.
Platinum | $10,000+
A la carte sponsorships include signage designating your organization as a sponsor during the sponsored event, badge recognizing you as a sponsor, and recognition on walk-in slides.
Want a custom sponsorship that fits your needs and budget? Contact partnerwithus@aspet.org to build your package today!
Mar
9-27
Division Town Halls
Apr
21
Registration Discounts End
May
17-20
ASPET 2026 Annual Meeting
20
GPCR Colloquium
Jun
8-23
Online Award Lectures