How does drug metabolism impact the development of precision medicine? Four new articles on this topic are now available in the special section “Drug Metabolism and Precision Medicine." Dr. Namandjé N. Bumpus and her trainees at Johns Hopkins School of Medicine contributed the research for the articles.

In this special section, Dr. Bumpus and her researchers address the fundamental knowledge in drug metabolism and precision medicine. Their contributing articles cover:

• the ways drug metabolism can directly impact therapeutic efficacy as well as risks for adverse reactions and drug toxicity;
• understanding how drug metabolism with single-cell analysis can provide unique insight into cell-to-cell heterogeneity for precision medicine;
• understanding how cell- and tissue-specific metabolism can advance precision medicine in the context of drug uses in the treatment of infectious diseases; and
• how analyzing the structure and function relationship of cytochrome P450 enzymes can improve prediction of the impact of genetic variations on drug metabolism in precision medicine.

Dr. Bumpus is the Chief Scientist at the U.S. Food and Drug Administration. She is the E. K. Marshall and Thomas H. Maren Professor of Pharmacology at Johns Hopkins University and serves as President-Elect of ASPET.

All content in the special section “Drug Metabolism and Precision Medicine” is available in the March 2023 (51/3) issue of Drug Metabolism and Disposition, and is freely accessible through October 2023.