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2020 Program Committee Blue Ribbon Picks

Blue RibbonUnder the direction of the ASPET Program Committee, more than 100 ASPET volunteers participating on 11 abstract review teams scored 900+ pharmacology abstract submissions. The ASPET Program Committee designated the top scoring abstracts as their Blue Ribbon Picks to assist members in finding the most exciting pharmacology research being presented at the meeting.

Pharmacology Education: Pedagogy

Using a "favorite figure" to help students learn challenging pharmacology topics
Katharina Brandl, University of California San Diego
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"Meet the Patient" Sessions: An Effective Pedagogical Approach for Teaching Pharmacology to Pre-clinical Medical Students
Gagani Athauda, Herbert Wertheim College of Medicine
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Pharmacology Education: Scholarship of Teaching and Learning

Does Attendance Credit Increase Medical Students’ Participation in In-class Lectures and Performance in Pharmacology?
Keshab Paudel, Trinity Medical Sciences University
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Branched Photoswitchable Tethered Ligands for Optical Interrogation of Metabotropic Glutamate Receptor-Mediated Modulation of  Prefrontal Cortex Circuits
Vanessa Gutzeit, Weill Cornell Medicine
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Central Effects of Diet

Effects of “Junk-Food” on Excitatory Transmission and NMDA Receptor Subunit Expression in the NAc of Females
Amanda France, University of Michigan
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Depression Mediated By Inflammatory Responses To Chronic Stress
Alexandros Kokkosis, Stony Brook University
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Long-term Antagonism of Mu Opioid Receptors by Methocinnamox (MCAM) without Adverse Effects on Memory
Vanessa Minervini, Creighton University
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RGS2 Modulates Cocaine Self-administration by Controlling Dopamine D2 Autoreceptor Activity
Deborah Luessen, Wake Forest School of Medicine
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Gap Junctions Modulate The Effects Of Modafinil On Cocaine Self-Administration Behavior In A Dopamine-Independent Fashion In Rats
Gianluigi Tanda, Medication Development Program, NIDA-IRP/NIH
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CRF Release in the Nucleus Accumbens Promotes Arousal in Anticipation of Cocaine Availability: Implications for Stress-Induced Drug-Seeking
Michael Leonard, Tufts University
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Beta-caryophyllene, a Volatile Phytocannabinoid, Attenuates Cocaine Self-administration and Relapse in Rats
Ewa Galaj, National Institute on Drug Abuse
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Real-time pharmacokinetic and pharmacodynamic measurements of drugs within the brains of freely behaving rats.
Kyle Ploense, UC Santa Barbara
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Traumatic Brain Injury and Stroke

Late Atomoxetine or Fluoxetine Treatment with Low Duration Voluntary Running Facilitate Recovery of the Motor Function after Photothrombotic Stroke in Mice
Faisal Alamri, Texas Tech University Health Sciences Center
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Allosterism and Biased Ligands

Structure-Activity Relationships of a Negative Allosteric Modulator of the D3 Dopamine Receptor and Investigation of its Binding Site
Amy Moritz, NINDS, NIH
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Cell Signaling and Spatiotemporal Kinetic Regulation

Mechanistic Dissection of Spatially Encoded GPCR Signaling Through High-throughput CRISPR Screening
Nikoleta Tsvetanova, Duke University
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GPCR Pharmacology and Signaling

A High-throughput CRISPR Interference Screen to Dissect Functional Regulators of GPCR/cAMP Signaling
Khairunnisa Semesta, Duke University
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GPR139 Signals Through Gq/11 to Oppose Mu Opioid Receptor Signaling
Hannah Stoveken, Scripps Research
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Modeling, Mutations and Structural Studies

Identifying β-arrestin1 conformational states by a non-GPCR binding partner
Ya Zhuo, Medical College of Wisconsin
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Receptor Trafficking, Desensitization and Internalization

Dissection of anterograde trafficking and sorting of GPCRs in primary neurons
Zhe Wei, Augusta University
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Second Messenger Pathways Receptors and Regulation

Impaired Autoinhibition of Protein Kinase Cγ in Spinocerebellar Ataxia Type 14
Caila Pilo, University of California, San Diego
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a-arrestin ARRDC3 is a Multifunctional Adaptor That Regulates G Protein-Coupled Receptor Signaling and Breast Cancer Invasion
Wen-An Pan, Department of Pharmacology, School of Medicine, University of California, San Diego
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G Protein Gamma Subunits: Phosphorylation-Mediated Governors of G protein Signaling in Humans?
Zahra Nassiri Toosi, Georgia Institute of Technology
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G protein βγ translocation to the Golgi activates the mitogen-activated protein kinases via phosphoinositide 3-kinase γ
Mostafa Khater, Medical College of Georgia - Augusta University
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Characterization of Drug Properties

CLIC1 is an Attractive Candidate for the Initial Binding Target of the Novel Peptide MTI-101
Sarah Freeman, West Virginia University
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Novel TRPA1 Antagonists are Multimodal Blockers of Human TRPA1 Channels: Drug Candidates for Treatment of Familial Episodic Pain Syndrome (FEPS)
Jeffrey Herz, Algomedix
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Discovery and structure-activity relationship study of novel series of mono-amine transporter inhibitors for the treatment of neurodegenerative diseases
Md Ashraf-Uz-Zaman, Texas Tech University Health Sciences Center
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Drug Discovery Platform Approaches

Discovery of high affinity γ-Hydroxybutyrate (GHB) Receptor Ligands for SSADH Deficiency, a Disorder of GABA Metabolism
Justin Chen, Washington State University
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Profiling the Signaling Repertoire of One Hundred Therapeutically-Relevant Human GPCRs
Arturo Mancini, Domain Therapeutics
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Identification of FDA approved drugs and their synergistic combinations as potent and selective regulators of uterine contractility for therapeutic control of preterm labor
Shajila Siricilla, Vanderbilt University Medical Center
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Translational Studies in Drug Development

Translational pharmacology of TD139, an inhaled small molecule galectin-3 (Gal-3) inhibitor for the treatment of idiopathic pulmonary fibrosis (IPF)
R. J. Slack, Galecto Biotech AB
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Light-Mediated Delivery of Dexamethasone for the Treatment of Rheumatoid Arthritis
Emilia Zywot, University of North Carolina
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General Toxicology

Development of a Pediatric Rodent Model to Characterize the Toxic Mechanisms of Inhaled Phosphine
Matthew Hartog, US Army Medical Research Institute of Chemical Defense
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Enhancing Stem Cell-based Toxicity Assays by Engineering the Culture Niche in a High-throughput, Assay-agnostic Manner
Nicholas Geisse, NanoSurface Biomedical
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Liver Toxicology

Investigating the Structure-Toxicity Relationship of Methylimidazolium Ionic Liquids in Isolated Primary Human Hepatocytes
Tarek Abdelghany, Institute Cellular Medicine, Newcastle University
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Brain Organoid-on-a-Chip: Model System for Predicting cART induced Neurotoxicity and Neuropsychiatric Effects
Tanya Chhibber, Texas Tech University Health Sciences Center
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Drug Metabolism and Disposition

Impact of Inter-individual Variability in CYP1A2 and CYP3A4 Activity on Sunitinib Metabolism
Klarissa Jackson, University of North Carolina at Chapel Hill
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Functions and Importance of Metabolic Enzymes

Postnatal loss of Cyp26a1 and Cyp26b1 in mice causes impaired retinoid homeostasis in multiple organs
Guo Zhong, University of Washington
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Tissue-specific Humanized Models Expressing Human UGT1A1
Elvira Mennillo, University of California San Diego
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Comparisons between Animal Models and Intestinal Crypt Cultures when Investigating the Impact of Fatty Acids on Gene Expression in Intestinal Epithelial Cells
Xiaojing Yang, University of California San Diego
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Pharmacokinetics and Others

Altered Cisplatin Pharmacokinetics during Nonalcoholic Steatohepatitis Contributes to Reduced Nephrotoxicity
Joseph Jilek, University of Arizona
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Differential Regulation of Hepatic UDP-glucuronosyltransferase (UGT) 1A1 by Toll-like Receptors during Irinotecan-induced Steatosis
Gabriel Tao, University of Houston
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Bioengineered miR-328-3p modulates SLC2A1/GLUT1-mediated glucose uptake and metabolism to exert synergistic antiproliferative effects with chemotherapeutics
Mei-Juan Tu, UC Davis School of Medicine
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PGRMC1 Stabilizes Cytochromes P450 And Is Required for Activity In Vivo
Meredith McGuire, Johns Hopkins University School of Medicine
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Renal Tubular Secretion of Dofetilide is Dependent on MATE1 Function
Muhammad Erfan Uddin, The Ohio State University
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Differential Contribution of Neuronal Uptake Transporters to Oxaliplatin Peripheral Neurotoxicity
Kevin Huang, The Ohio State University
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Anticancer Drug Response

Gilteritinib Inhibits Acute Myeloid Leukemia Growth via Reduction in Glutamine Uptake and Utilization
Megan Zavorka Thomas, The Ohio State University
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Cancer Drug Discovery

Novel Small Molecule Compound Disrupts the SIX1/EYA2 Complex and Inhibits Breast Cancer Metastasis
Hengbo Zhou, University of Colorado, Anschutz Medical Campus
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Childhood Cancer Drug Development: Why Alternative Designs for Drug Development are Required
Peter Houghton, Greehey Children's Cancer Res. Inst.
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Cancer Immunotherapy

Small-Molecule Sigma1 Modulator Suppresses PD-L1-Mediated Cancer Cell Adaptive Immune Resistance in Response to Interferon-Gamma
Derick Haas, Sidney Kimmel Cancer Center at Thomas Jefferson University
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Drug Targets in Cancer

Autophagy Inhibition Sensitizes Liver Kinase B1 (LKB1)-Deficient Kras-Driven Lung Tumors to MEK Inhibitor Trametinib
Vrushank Bhatt, Rutgers Cancer Institute of New Jersey
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Cardiac Pharmacology

Rap1 exacerbates myocardial ischemia/reperfusion injury through activation of NFκB signaling pathway and NLRP3 inflammasome
Yin Cai, The University of Hong Kong
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Cardiac AKAP12 Signalosome Overexpression Exacerbates Isoproterenol Induced Heart Failure
Hanan Qasim, University of Houston
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Role of Thioredoxin-interacting Protein in Diabetic Myocardial Ischemia-Reperfusion Injury
Xiaodong Ye, The University of Hong Kong
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Cardiovascular Pharmacology

Differential Protein-Protein Interactions Driven by the Arg/Gly389 Single Nucleotide Polymorphisms in the Cardiac Beta-1 Adrenergic Receptor
Christina Bloomfield, Des Moines University
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Open Heart Surgery with Cardiopulmonary Bypass using Dexmedetomidine-based Monitored Anesthesia Care without Endotracheal intubation Improves Postoperative Recovery
Wenting Chen, Dept. of Anesth., Shuguang Hosp. Affiliated to Shanghai Univ. of Traditional Chinese Med.
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Pilot Evaluation of Telemetered Cardiac Hemodynamics in the Setting of Fully-Implanted Programmable Drug Delivery in Rats:  A New Tool for Cardiovascular Drug Discovery?
Nikki Bennett, Myokardia
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Reshaping commensal gut microbiota in early life lowers blood pressure potentially via a succinate mediated mechanism
Saroj Chakraborty, University of Toledo
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Vascular Pharmacology

Novel Contributions of Neutrophil-derived Myeloperoxidase and Hypochlorous Acid to 20-HETE Production that drives Post-Ischemic Angiogenesis
Juan Azcona, New York Medical College
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Opioids Cause Vascular Remodeling via Changes in Cofilin-ERK Signaling: Female Mice Present Higher Risk of Developing Morphine-induced Cardiovascular Disease than Male Mice
Soyoung Cheon, University of Toledo College of Medicine and Life Sciences
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Stimulation of Angiotensin II Receptor 2 Preserves Cognitive Function Post Stroke and is Associated with an Enhanced Cerebral Vascular Density in Female Rats
Wael Eldahshan, Program in Clinical and Experimental Therapeutics, Charlie Norwood VA Medical Center and University of Georgia College of Pharmacy
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Clinical and Preclinical Pharmacology

Pharmacokinetic Prediction of CYP2D6 Genotypes of Metoclopramide in Adults and Children Using Physiologically Based Pharmacokinetic Modeling
Hyo-Bin Shin, Sungkyunkwan Univ.
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A Randomized, Placebo-Controlled, Double-Blind Clinical Investigation on a Patent-Pending KD120 Metabolically Activated Enzyme Formulation, N-SORB, in Healthy Young Volunteers
Sreejayan Nair, University of Wyoming School of Pharmacy
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GI Pharmacology

TAK-906, a Novel D2/D3 Receptor Antagonist:  First-in-Human Study of Single and Multiple Ascending Doses
Roger Whiting, Altos Therapeutics, LLC
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Therapeutic Intervention Targeting Mucosal Thrombin Or Protease-Activated-Receptor 1 Are Protective Against Colitis
Jean-Paul Motta, INSERM
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Translational Research

A highly potent lymphatic system-targeting nanoparticle-cyclosporine with efficacy in a lupus mouse model
Raghu Ganugula, Texas A&M Irma Lerma Rangel College of Pharmacy
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Therapeutic anti-P2X4 receptor scFv antibody for chronic neuropathic pain
Adinarayana Kunamneni, Loyola University Chicago
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Serum-derived Extracellular Vesicles as Diagnostic Biomarkers for Non-alcoholic Fatty Liver Disease
Lauren Newman, Flinders University
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Pharmacodynamics and Signal Transduction

CD44-Targeted Monoclonal Antibody is Anti-Inflammatory in an In-Vivo Model of Monosodium Urate Crystal Induced Peritonitis
Emira Bousoik, Chapman University School of Pharmacy
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Last Updated: June 15, 2020
Key Dates
March 6

Housing discounts end

March 13

Advance Registration Ends

April 3-4

GPCR Colloquium (separate ticket required)

April 4

ASPET Business Meeting and Awards Presentation

April 4-7

ASPET Annual Meeting at EB 2020

Thank you to our Annual Meeting partners:

University of Kentucky
Icahn School
University of Georgia
University of Minnesota
WSU Pharm-Pharm Sciences Unit
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