In This Section

Norman Weiner Lecture
Washington Convention Center, Room 143 A/B
8:30 am - 9:20 am

Robert J. Lefkowitz, Duke Univ. and HHMI

      Seven Transmembrane Receptors: Something Old, Something New

New Roles for Arrestins in Signaling, Trafficking and Disease
Washington Convention Center, Room 143A/B
9:30 am – 12:00 noon
Sponsored by the Divisions for Molecular Pharmacology and Integrative Systems, Translational & Clinical Pharmacology
Chair: J.L. Benovic, Thomas Jefferson Univ.


Mechanistic insight into arrestin-mediated trafficking
    Jeffrey L. Benovic, Thomas Jefferson University 

Behavioral selectivity of arrestin-dependent dopamine mediated signaling
  Marc G. Caron, Duke University Medical Center 

Beta-arrestin1 signaling and auto-immunity
    Gang Pei, Shanghai Institutes for Biological Sciences 

Arrestin-related ubiquitin-ligase adaptors required for endocytosis and PM protein down-regulation
    Scott Emr, Cornell University Weill Institute for Cell and Molecular Biology

Retromer terminates the generation of cAMP by internalized G-protein-coupled PTH receptors
Timothy N. Feinstein, Univ of Pittsburgh

 Novel insights into the role of arrestin-2 in endosomal sorting of CXCR4
    Rohit Malik, Loyola Univ Chicago


Cardiovascular KCNQ (Kv7) Potassium Channels: Physiological Regulators and Targets for Therapeutic Intervention
Washington Convention Center, Room 140B
9:30 am – 12:00 noon
Sponsored by the Divisions for Cardiovascular Pharmacology; Drug Discovery, Development & Regulatory Affairs; Integrative Systems & Translational & Clinical Pharmacology; and Molecular Pharmacology
Chairs: K.L. Byron, Loyola Univ. Strich Sch. of Med. and D.L. Kunze, MetroHealth Med. Ctr

Expression and function of KCNQ genes in the vasculature
    Iain Greenwood, St. George's University, London

Vascular KCNQ channels as physiological signal transducers and novel targets for treatment of cardiovascular diseases
    Kenneth L. Byron, Loyola University of Chicago, Stritch School of Medicine

KCNQ channels as a therapeutic target in pulmonary hypertension
    Alison Gurney, University of Manchester, UK

KCNQ channels in the reflex regulation of arterial pressure
    Diana L. Kunze, MetroHealth Medical Center

M channels in regulation of cardiomyocyte contraction and in neuroprotection during stroke
     Mark Shapiro, University of Texas HSC, San Antonio

Elucidating new mechanisms in vasoconstrictor signal transduction:  Inhibition of Kv7.5 channel activity by PKCα
    Valerie Hummert, Loyola Univ Chicago

Chronobiology in the Modern Curriculum - Addressing Disease Linkage and Pharmacological Approaches
Washington Convention Center, Room 143C
9:30 am – 12:00 noon
Sponsored by the Divisions for Neuropharmacology and Pharmacology Education; Behavioral Pharmacology and Integrative Systems,Translational & Clinical Pharmacology
Chair: M.W. Wood, AstraZeneca Pharmaceuticals and S. Tischkau, Southern Illinois Univ.

An overview of Circadian clock dysfunction and disease
Shelley A. Tischkau,
Southern Illinois Univ School of Medicine

Pharmacological approaches to the treatment of sleep and wake disorders
John Renger,
Merck Research Laboratories

Translational applications of biological rhythm research: clinical chronobiology and chronotherapeutics
    Michael H. Smolensky, Univ. of Texas Hlth. Sci. Ctr. at Houston

In cancer, as in all else: timing is everything
    William J. Hrushesky, Dorn Veterans Affairs Medical Center

Pharmacogenomics and Personalized Medicine
Washington Convention Center, 140A
9:30 am – 12:00 noon
Sponsored by the Divisions for Integrative Systems, Translational & Clinical Pharmacology; Drug Discovery, Development & Regulatory Affairs; Drug Metabolism; and Toxicology
Chair: A. Gaedigk, Children’s Mercy Hospitals and Clinics

Pharmacogenetics to pharmacogenomics
    Richard Weinshilboum, Mayo Clinic College of Medicine

Pharmacogenetics and personalized medicine:  Facing the challenges of bridging the gap between science and utility
     Darrell Abernethy, FDA

From clinical utility to clinical effectiveness:  A real world perspective on pharmacogenetics in clinical practice
    Eric Stanek, Medco Health Solutions, Inc.

Incorporating pharmacogenetics into drug development
    William Macias, Eli Lilly and Co.

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