In This Section

Women in Pharmacology Career Roundtable
Washington Convention Center, Room 142
1:00 pm - 3:00 pm

Drug Metabolism Early Career Achievement Award Lecture
Washington Convention Center, Room 140B
2:00 pm - 2:50 pm

Emily Scott, Univ. of Kansas
      (CYP)2B, or not 2B: that is the question

Drug Metabolism Division and James Gillette Award Platform Sessions
Washington Convention Center, Room 140B
3:00 pm – 5:30 pm 

      Ecto-5'-nucleotidase and thiopurine cellular circulation:  Association with cytotoxicity
F. Li, Novartis Institutes for Biomedical Research

     Identification of constitutive androstane receptor (CAR) activators by integrated computational and biological approaches
         C. Lynch, Univ Maryland, Baltimore

     Crystal structure of prinomastat bound human cytochrome P450 2D6
        A. Wang, The Scripps Institute

      Evalutaion of 4',6-diamidino-2-phenylindole as a fluorescent probe substrate for rapid assays of the functionality of human multidrug and toxin extrusion proteins
  T. Yasujima, Nagoya City Univ

      A novel small nucleolar RNA-derived microRNA-1291 targest multidrug resistance-associated protein 1 (MRP1/ABCC1)
Y. Pan, State Univ of New York at Buffalo

      Purification and characterization of a molecular mimic of Phospho-ser348 in human cytosolic sulfotransferase (SULT) 2B1b
          E. D. Salman, Univ of Alabama at Birmingham

Integrative Systems, Translational and Clinical Pharmacology Division Young Investigator Awards Platform Session
Washington Convention Center, Room 141
3:00 pm – 5:30 pm

Neuropharmacology Division Postdoctoral Scientist Award Finalists
Washington Convention Center, Room 140A
3:00 pm – 5:30 pm

Organ-Specific Toxicities Caused by Novel Metabolic Pathways
Washington Convention Center, Room 143C
3:00 pm - 5:30 pm
Sponsored by the Divisions for Toxicology; Drug Metabolism; and Integrative Systems,Translational & Clinical Pharmacology
Chair: K. Skordos, GlaxoSmithKline

    Konstantine Skordos, GlaxoSmithKline

Selective expression and biotransformation mechanisms of lung P450 enzymes
    Christopher A. Reilly, University of Utah

Adrenal steroidogenic enzymes-mediated metabolism of xenobiotics leading to toxicities
    Jinping Gan, Bristol-Myers Squibb

CYP enzymes in the brain:  Organ specific regulation and impact on pharmacology
    Rachel Tyndale, University of Toronto

The role of ovarian metabolism in chemical-induced ovotoxicity
    Patricia Hoyer, University of Arizona Health Science Center

Function of P450 enzymes in the small intestine
    Qing-Yu Zhang, New York Department of Health, Wadsworth Center

Gα Subtype-Selective Signaling by GPCRs as a Substrate for Functional Selectivity
Washington Convention Center, Room 143A/B
3:00 pm – 5:30 pm
Sponsored by the Divisions for Drug Discovery, Development & Regulatory Affairs and Molecular Pharmacology
Chair: R. Neubig, Univ. of Michigan

 Introduction/Using RGS-insensitive mutants of Gi and Go dissect specific receptor pathways in vivo

    Rick Neubig, University of Michigan

Unique contributions of 5HT1A/Gαi2 signaling to antidepressant mechanisms
    John Traynor, University of Michigan

Selective regulation of G protein activation by the poorly characterised GPCR GPR35
    Graeme Milligan, University of Glasgow, UK

Antiepileptogenic actions of α2A adrenergic receptors acting via Gα-o in the hippocampus
    Van Doze, University of North Dakota

Physiological functions of G12 and G13
    Stefan Offermanns, Max-Planck-Institute for Heart and Lung Research




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