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GPCR Colloquium

Joint Colloquium on G Protein-Coupled Receptors: Evolving Insights from Pharmacology, Biochemistry and Physiology

Joint Colloquium on G Protein-Coupled Receptors: Evolving Insights from Pharmacology, Biochemistry and Physiology

Hosted by ASPET, ASBMB, and APS

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Monday, May 10 – Tuesday, May 11, 2021

Tremendous scientific advancements over the last decade indicate that GPCR physiology and pharmacology are much more complex than originally thought and that it may be possible to exploit this complexity to treat a wide variety of diseases. The objective of this colloquium is to expose scientists to recent discoveries and multidisciplinary approaches used to study GPCRs and provide opportunities for establishing collaborations that bridge complementary interests. The event will feature speakers who have made exciting discoveries in GPCR research that range from molecular to systems biology, basic research to translational studies, and pharmacology to biochemistry to physiology.



Tracy M. Handel – University of California, San Diego
Paul Insel – University of California, San Diego
Jennifer Pluznick - Johns Hopkins University School of Medicine


View session times and schedule details on EB platform


Brian Kobilka - Stanford University
Structural Insights into the Dynamic Process of G Protein–Coupled Receptor Activation


Systems Biology Approaches to GPCR Physiology and Pharmacology

Mark Knepper – NHLBI
V2R-omics: Multi-systems Approaches to Define Vasopressin Action

Nina Wettschureck – Max Planck Institute for Heart and Lung Research
Signal Cell Analysis of GPCR Expression: Implication for Physiology and Pathophysiology

Kirill Martemyanov - The Scripps Research Institute
Deciphering Diversity of GPCR Signaling

Sriram Kosuri - Univ. of California, Los Angeles
Combining Synthesis and Multiplexed Assays to Explore Human Biology: GPCRs as a Paradigm

GPCR Structural Biology and Drug Discovery

Chris Tate – Cambridge Univ.
Molecular Basis for High-affinity Agonist Binding at the Beta1-adrenoceptor

Bryan Roth – Univ. of North Carolina
New Technologies for Structure-guided GPCR Drug Discovery

Minghong Ma – Univ. of Pennsylvania
G Protein–Coupled Olfactory Receptors:  Novel Insights into Responsiveness and Mechano-Sensitivity

Laura Wingler – Duke Univ.
Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor

GPCRs in Pathophysiology and Pathobiology

Jerold Chun - Sanford Burnham Prebys.
Lysophospholipid - LPA and S1P - Receptors in Brain Disorders and Therapeutics

Kathleen Caron – Univ. of North Carolina
Novel Regulatory Functions of GPCRs in Vascular Growth and Remodeling

Willis (Rick) Samson – St. Louis Univ.
Novel Peptide-activated (Orphan) GPCRs: New Insights and Therapeutic Opportunities

Lora Heisler – Univ. of Aberdeen
Targeting GPCRs to Improve Obesity

GPCR Short Talks

Matthew Eddy – Univ. of Florida
Structural Insights into Activation of a Human G Protein-Coupled Receptor by Membrane Phospholipids

Qiuyan Chen - Purdue Univ.
Structure of the Rhodopsin–rhodopsin Kinase Complex Defines the Rules of Engagement Between G Protein-coupled Receptors (GPCRs) and GPCR Kinases

Ivan Maslov - Moscow Inst. of Physics and Technology
Structural Dynamics of the A2A Adenosine Receptor Revealed by Single-molecule

Khairunnisa Mentari Semesta - Duke Univ.
A High-throughput CRISPR Interference Screen for Dissecting Functional Regulators of GPCR/cAMP Signaling

Taeyeop Park - McGovern Med. Sch. at Univ. of Texas Health Science Center
BioID-Based Network Analysis to Probe Alterations and Functional Consequences of Adenylyl Cyclase-Containing Macromolecular Complexes in Cardiomyocytes

Caitlin A.D. Jagla - Duke Univ.
Post-Transcriptional Regulation of Cellular Responses to GPCR Signaling

Antonio Garcia Soares – Univ. of Texas Health Science Center at San Antonio
Gs-DREADD Regulation of ENaC

Nicholas Kapolka – Univ. of Miami, Miller Sch. of Med.
Proton-gated Coincidence Detection Is a Common Feature of GPCR Signaling

Brian G.Poll - NHLBI
GPCR-omics of the Nephron: Mapping Receptors Along the Renal Tubule

Closing Talk

R. Scott Prosser – Univ. of Toronto
NMR Inspired Studies of GPCR Activation and the Connection to Pharmacology - A Non-Wikipedia Perspective

Virtual Posters

The co-chairs curated 150 GPCR-related abstracts for a special poster session on May 10-11 that includes pharmacology, physiology, and biochemistry. Virtual posters at the Colloquium include a PDF poster with a 5-minute audio narration by the author as well as a text-based Q&A discussion board. You can also reach out to authors privately through the written chat function or request a 1:1 video chat.

Nine poster finalists will be announced during the meeting and attendees will vote on the best poster with prizes awarded to the top 3 on May 11.


Thanks to the generosity of our sponsors and support from ASPET, ASBMB, and APS, a ticket for the colloquium is being provided at no extra charge with your paid registration to Experimental Biology.  Use your login credentials from EB to participate in the GPCR Colloquium. 


Society Partner Support

American Society for Pharmacology and Experimental Therapeutics
American Society for Biochemistry and Molecular Biology
American Physiological Society

Gold Level Support

Arena Pharmaceuticals, Inc.
Multispan, Inc.
Montana Molecular
British Journal of Pharmacology
Crinetics Pharmaceuticals

Silver Level Support

CuraSen Therapeutics Inc.

Bronze Level Support

Journal of Biological Chemistry

ASPET Division Support

Division for Molecular Pharmacology
Division for Drug Discovery and Development
Division for Neuropharmacology

Arena Pharmaceuticals
Multispan Assay Experts in GCPRs and Beyond
Montana Molecular: Flourescent Biosensors for Live Cell Discovery
JBC Journal of Biological Chemistry


British Journal of Pharmacology

CuraSen Therapeutics



Crinetics Logo



Learn how your organization can support the colloquium. Contact or (301) 634-7060.


Last Updated: May 12, 2021
Key Dates
April 27 – 30, 2021

ASPET Annual Meeting at EB 2021

Thank you to our Annual Meeting partners:

PR & P