In This Section

Behavioral Pharmacology Division Symposium:  Pharmacokinetic Approaches to the Treatment of Drug Abuse
Washington Convention Center, Room 140A
3:00 pm – 5:30 pm
Chairs: G.T. Collins, Univ. of Michigan and C.R. Schuster, CRS Associates, LLC

Introduction to the protein-based approach for treating drug addiction
    James H. Woods, Univ of Michigan

Rationally designed mutant cocaine esterases:  Dramatic improvements in the thermostability and duration of action
   Diwahar Narasimhan, Univ of Michigan

Preclinical evaluation of cocaine esteraes for the treatment of cocaine overdose and addiction
   Gregory T. Collins, Univ of Michigan

Development of immunotherapies and nanoparticle conjugates for the treatment of methamphetamine abuse
   Eric C. Peterson, Univ of Arkansas for Medical Sciences

Nicotine immunotherapies: Pharmacokinetics, behavior and clinical trials
   Paul R. Pentel, Univ of Minnesota

Effectiveness of cocaine-specific vaccines in humans
   Margaret Haney, Columbia Univ College of Physicians and Surgeons

  James H. Woods, Univ of Michigan

Drug Discovery, Development and Regulatory Affairs Symposium: High Impact Pharmacological Screening in Academia
Washington Convention Center, 143 A/B
3:00 pm – 5:30 pm
Co-sponsored by the Division for Molecular Pharmacology
Chair: J.S. Lazo, Univ. of Virginia

Introduction: high impact pharmacological screening in academia.
  John S. Lazo, Univ. of Virginia    

Harvesting the fruits of small molecule screening targeting neglected diseases.
  John S. Lazo, Univ. of Virginia  

Protein-protein interaction space for small molecule modulator discovery through high throughput screening.
  Haian Fu, Emory Univ. 

Chemical probes for the genome era.
  Christopher Austin, NHGRI, NIH

Molecular repurposing: discovering new molecular targets for known drugs.
  Bryan L. Roth, Univ. of North Carolina 

Pharmacology Education Division Course: What Happens to Drugs in the Body? A Pharmacokinetics Refresher Course
Grand Hyatt Hotel, Independence H/I
3:00 pm – 5:30 pm
Chairs: J.S. Fedan, NIOSH and J.S. Leeder, Children’s Mercy Hospital and Clinics

Basic concepts in pharmacokinetics
  Cheryl Zimmerman, Univ of Minnesota

Applying pharmacokinetic principles to drug discovery
   Gary Skiles, Amgen, Inc.

The package insert:  What's behind it?
   Timothy S. Tracy, Univ of Minnesota

Toxicology Division Symposium: Hypoxia, Hypoxia-Inducible Factor-1α and Toxic Responses
Washington Convention Center, Room 143C
3:00 pm – 5:30 pm
Chair: P.E. Ganey. Michigan State Univ.

HIFs, hypoxia, and effects on development, physiology, and disease
Brian Keith, Univ of Pennsylvania Abramson Family Cancer Research Inst.

Hypoxia and drug-induced liver injury
  Robert A. Roth, Michigan State Univ

Hypoxia, nitric oxide, and mitochondrial dysfunction in nonalcoholic fatty liver disease
  Shannon M. Bailey, Univ of Alabama at Birmingham

Critical role of hypoxia-inducible factors in the development of liver fibrosis
  Bryan L. Copple, Univ of Kansas Medical Center

The role of hypoxia inducible factors in toxicant-induced lung injury
  John LaPres, Michigan State Univ

Cardiovascular Pharmacology Division Trainee Showcase
Washington Convention Center, Room 140B
2:30 pm – 5:30 pm

SUMOylation of NADPH oxidases negatively regulates reactive oxygen species production
  Deepesh Pandey, Medical College of Georgia 

Role of caveolins in epoxyeicosatrienoic acid mediated protective effect against ischemia reperfusion injury
  Ketul Chaudhary, Univ. of Alberta, Edmonton, AB, Canada

Polyphenol-eluting stent reduces restenosis and promotes vascular healing in a rat model of arterial angioplasty and stenting
  James J. Kleinedler, Louisiana State Univ. HSC

Upregulation of vascular L-type calcium channels during hypertension is blunted in the absence of accessory ß3 subunits
  Sujay V. Kharade, Univ. of Arkansas for Medical Sciences  

Prenatal hypoxia programs vascular endothelin-1 activity in adult offspring
  Stephane Bourque, Univ. of Alberta, Edmonton, AB, Canada

Novel Epoxyeicosatrienoic Acid (EET) analogs increase sodium excretion and lower blood pressure in hypertension
  Abdul Khan, Medical College of Wisconsin

Benedict R. Lucchesi Distinguished Lecture in Cardiac Pharmacology

Washington Convention Center, Room 140B
4:30 pm - 5:30 pm

David J. Lefer, Emory Univ.          
Hydrogen sulfide and the cardiovascular system:  deadly toxin or promising therapeutic




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