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New Strategies for Augmenting Immune Checkpoint Blockade in Cancer Therapy

Saturday April 06, 2019

11:00 am - 1:00 pm

Room W205 A
Sponsored by the Division for Cancer Pharmacology (DCP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Molecular Pharmacology (MP)

Chair :

John Lazo
University of Virginia

Christine Canman
University of Michigan

Immune Checkpoint Blockade is a powerful new weapon against cancer. Unfortunately, only a fraction of patients achieve remission. Current research is directed towards finding biomarkers that would help identify likely responders and develop new therapeutic approaches to transform non-responders to responders. This symposium will provide a historical perspective on the field of immune-oncology and discuss recent progress in identifying new strategies for boosting the efficacy of immune checkpoint inhibitors through combination therapy with ATM and DNA methylation transferase inhibitors.

Reversing Exhaustion-associated DNA-methylation Programs to Re-invigorate Exhausted Cytotoxic T Cells and Improve Immune Checkpoint Inhibitors Response
Benjamin Youngblood - St. Jude Children’s Research Hospital

Epigenetic Activation of the Interferon Response to Sensitize Cancers to Immune Therapy
Katherine Chiappinelli - The George Washington University School of Medicine and Health Sciences

Inhibition of the ATM Kinase – A New Approach to Enhancing Immune Therapy for the Treatment of Pancreatic Cancer
Michael Green - University of Michigan

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology