The Drug Metabolism and Disposition November issue features 24 commentaries, minireviews, and original research articles on novel models of drug metabolism and disposition. Dr. Aarti Sawant-Basak and Dr. R. Scott Obach were the Guest Editors for the special section.
The content covers novel static or micro-flow based models of the intestine, liver, eye, and kidney. Static intestinal systems like mucosal scrapings and cryopreserved intestinal enterocytes, as well as novel bioengineered or chemically engineered intestinal models derived from primary human tissue, iPSCs, enteroids, and crypts are included. Experts have reviewed hepatic systems like cryopermeabilized Metmax hepatocytes and longer term, hepatocyte coculture system from HµREL, yielding in vivo-like primary and secondary drug metabolite profiles. Minireviews also discuss applications laboratory animals and humanized mice models of CYP450, UGT, and oatp1a4 as well as in vitro and in vivo models of drug metabolism derived from genetic, chromosomal, and tissue engineering techniques. Additional liver models, including micropattern hepatocyte coculture, 3D liver spheroids, and microflow systems, applicable to the study of drug disposition and toxicology have also been reviewed. Ocular disposition models including corneal permeability models are included, as is commentary on in vitro and in vivo models of drug metabolism derived from breakthrough genetic, chromosomal, and tissue engineering techniques.
The special section is available on the DMD website. All of the special section content is freely accessible through January 15, 2019.