This DMD Special Section of “Bile acids, drug metabolism, and toxicity” includes five featured review articles and one research article that focuses on bile acids, drug metabolism, and toxicity. The review articles cover molecular mechanisms in regulation of bile acid homeostasis; environmental chemical contribution to the modulation of bile acid homeostasis through FXR signaling; the role of PXR in gut-liver interactions on drug metabolism and toxicity; a novel approach for diagnosing nonalcoholic steatohepatitis by applying advanced pharmacokinetic biomarkers; the role of Nrf2 in allergy and asthma; and the mechanisms for alterations of drug metabolism by thyroid hormones. The research article highlights effects on drug metabolism by overexpression of FGF15/19. 

All articles in the special section found in Drug Metabolism and Disposition April 2022 (50/4) issue are freely accessible through October 31, 2022.