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G protein Signaling in Neuropsychiatric Disorders

Tuesday April 07, 2020

2:00 pm - 3:30 pm

Room 16 A
Sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Neuropharmacology (NEU)

Chair :

Qin Wang
University of Alabama

Venetia Zachariou
Icahn School of Medicine at Mount Sinai


Dysregulation of GPCR function in the brain underlies numerous neuropsychiatric disorders. This symposium provides insights from preclinical studies on the regional specificity of GPCR signaling in the brain and on signal transduction adaptations observed under pathological conditions. The speakers share latest findings on the precise role of Regulators of G protein signaling, allosteric regulation of receptor signaling, and complexes between G protein beta subunits and SNARE proteins, in disease-induced plasticity and monoamine receptor function. The panel will discuss potential therapeutic avenues targeting G protein signaling components for treatment of neuropsychiatric disorders such as pain, Parkinson’s disease and Alzheimer’s disease.

Amyloid β Hijacks Norepinephrine Signaling to Activate the Pathogenic GSK3β/tau Cascade
Qin Wang - University of Alabama

Disabling Gβγ-SNARE Interaction Disrupts GPCR-mediated Presynaptic Inhibition Leading to Physiological and Behavioral Phenotypes
Heidi Hamm - Vanderbilt University Medical Center

RGS4 Maintains Chronic Pain Symptoms in Rodent Models
Venetia Zachariou - Icahn School of Medicine at Mount Sinai

Age-dependent Nigral Dopaminergic Neurodegeneration in RGS6-Deficient Mice
Rory Fisher - University of Iowa

Last Updated: November 8, 2019
Key Dates
March 6

Housing discounts end

March 13

Advance Registration Ends

April 3-4

GPCR Colloquium (separate ticket required)

April 4

ASPET Business Meeting and Awards Presentation

April 4-7

ASPET Annual Meeting at EB 2020

Thank you to our Annual Meeting partners:

Univ_Wisconsin
UT_Health_SanAntonio
University of Kentucky
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Icahn School
University of Georgia
University of Minnesota
WSU Pharm-Pharm Sciences Unit
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