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Molecular Pharmacology Highlighted Trainee Author, December 2017

November 16, 2017

Renee Bouley Dr. Renee Bouley is the Molecular Pharmacology Highlighted Trainee Author for December 2017.

Dr. Bouley is currently a postdoctoral fellow in the Department of Pharmacology at the University of Michigan. The Molecular Pharmacology article that earned her selection as a Highlighted Trainee Author is titled Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.

Dr. Bouley’s area of research is the structural biology of G protein-coupled receptor kinases. She is currently working to elucidate the roles that G protein-coupled receptor kinases (GRK) 2 and 5 play in heart failure by utilizing several novel GRK inhibitors. She is using a combination of X-ray crystallography and in vitro cellular receptor internalization assays to understand how these inhibitors effect biochemical pathways implicated in heart disease, such as beta-adrenergic receptor desensitization.With respect to impact, Dr. Bouley’s current research could establish that selective inhibitors of GRK2 or GRK5 are potential therapeutic agents for the treatment of heart failure. Additionally, selective inhibitors will be important chemical probes that will enable us to better understand how these kinases regulate multiple processes involved in heart failure

When not in the lab, Dr. Bouley enjoys horseback riding. She rides hunter/jumper styles and hopes to compete in a show next year.

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