Is there anything new to be known about GPCRs? Of course there is! Here in this cluster of Molecular Pharmacology articles the use of computational approaches to tease apart some of the more recent and exciting aspects of GPCR function are discussed. The reviews cover the impact that the cell membrane environment can exert on ligand binding to GPCRs, the current status of ligand bias with a focus on opioid receptors, and the nature of peptide binding to class A GPCRs.

The cluster of articles, which appear in the November issue, is freely accessible through the end of 2019.