Eleanor Jing Yi Cheong is the Drug Metabolism and Disposition Highlighted Trainee Author for the November 2019 issue. Ms. Cheong is a pre-doctoral trainee in the Department of Pharmacy at the National University of Singapore. Her mentor is Prof. Eric Chun Yong Chan. The Drug Metabolism and Disposition article that earned her selection as a Highlighted Trainee Author is titled "Systematic Development and Verification of A Physiologically-Based Pharmacokinetic Model of Rivaroxaban" and is available at http://dmd.aspetjournals.org/content/47/11/1291.
Ms. Cheong’s current research focuses on the optimization of pharmacotherapy in both cardiology and prostate oncology. She is working on utilizing bottom-up physiologically-based pharmacokinetic modeling incorporating in vitro data to mechanistically quantify complex albeit untested drug-drug interactions involving direct oral anticoagulant, rivaroxaban. Additionally, Ms. Cheong is also interested in investigating how the highly variable pharmacokinetics of steroidogenic CYP17A1 inhibitor abiraterone may influence target exposure, drug-target binding and ultimately therapeutic efficacy.
The anticipated impact of Ms. Cheong’s research is to demonstrate how modeling and simulation approaches can enhance precision dosing in clinical care and aid the optimization of dosing strategies.
When not in the lab, Eleanor enjoys rock climbing and traveling.