In This Section

News Detail

Drug Metabolism and Disposition Highlighted Trainee Author, October 2020

September 23, 2020

Jia Yumeng

Yu-Meng Jia is the Drug Metabolism and Disposition Highlighted Trainee Author for the October 2020 issue. Dr. Jia is a post-doctoral trainee at the Xi’an Jiaotong University School of Public Health, Xi’an, China. In June 2019, Dr. Jia completed her PhD training program in the Department of Clinical Pharmacology at the College of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, and the General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, China. Her graduate mentor was Dr. Hong-Guang Xie. The Drug Metabolism and Disposition article that earned her selection as a Highlighted Trainee Author is titled “Multidrug Resistance-Associated Protein 3 is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood” and is available at https://doi.org/10.1124/dmd.119.089193.

During her PhD studies, Dr. Jia was actively involved in the Mrp3-mediated efflux transport of the glucuronide metabolites of certain traditional Chinese medicines in mice, such as curcumin, wogonin, oroxylin A, and more. In addition, Dr. Jia was also interested in the study of the hydrolysis of vicagrel and aspirin in the intestine by hydrolases, such as arylacetamide deacetylase and carboxylesterase 2, and the mechanisms underlying drug-drug interactions  during concomitant use . Currently, Dr. Jia is working on the screening and discovery of new targets and drugs for the effective treatment of Kashin-Beck disease, an endemic chronic osteoarthritis present frequently in some Northwestern provinces of China, by the combined use of multiple -omics and bioinformatics.

The anticipated impact of her research is to help better understand the metabolism of the drugs of interest (such as the antiplatelet drugs) via enzymatic oxidation and hydrolysis pathways in the body and the mechanisms involved. The research papers summarized in her PhD thesis would add new pieces of drug metabolism and disposition information to the puzzle of antiplatelet precision therapy in the future, providing novel insights into the optimal use of these drugs for patient care.

When not in the lab, Yu-Meng enjoys playing flute and pipa (a traditional Chinese music instrument). She also enjoys Chinese painting, swimming, and skating.

Related Files:
Categories:
  • Journal News
Last Updated: September 18, 2019

Job Postings